Sugi Predict

Sugi Predict / Compounds / SCHEMBL5380472

SCHEMBL5380472

SCHEMBL5380472

CC(C)(C)[Si](C)(C)O[C@@H]1CCC[C@@H]1O

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ NPY1R P25929 1/20 0.38
▸ NPY2R P49146 1/20 0.38
▸ NPY4R P50391 1/20 0.38
▸ NPY5R Q15761 1/20 0.38
▸ PPM1D O15297 2/20 0.36
▸ GSR P00390 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7464146 1.00 NPY1R (0.38) NPY1RNPY2RNPY4RNPY5RPPM1D
SCHEMBL7464139 1.00 NPY1R (0.38) NPY1RNPY2RNPY4RNPY5RPPM1D
SCHEMBL5380480 1.00 NPY1R (0.38) NPY1RNPY2RNPY4RNPY5RPPM1D
SCHEMBL5380476 1.00 NPY1R (0.38) NPY1RNPY2RNPY4RNPY5RPPM1D
SCHEMBL13573044 0.96 NPY1R (0.41) NPY1RNPY2RNPY4RNPY5RPPM1D
SCHEMBL13573075 0.94 NPY1R (0.40) NPY1RNPY2RNPY4RNPY5RPPM1D
SCHEMBL13573064 0.94 NPY1R (0.40) NPY1RNPY2RNPY4RNPY5RPPM1D
SCHEMBL1989059 0.89 PPM1D (0.35) NPY1RNPY2RNPY4RNPY5RPPM1D
SCHEMBL18049618 0.89 PPM1D (0.35) NPY1RNPY2RNPY4RNPY5RPPM1D
SCHEMBL1989437 0.89 PPM1D (0.35) NPY1RNPY2RNPY4RNPY5RPPM1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2678329-B1 TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2015-11-18 — — EP disclosed
US-8889704-B2 Triazolopyridine compounds as PIM kinase inhibitors ARRAY BIOPHARMA INC. (US) 2014-11-18 — — US disclosed
US-20140005213-A1 TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2014-01-02 — — US disclosed
US-20090312559-A1 CATALYTIC ENANTIOSELECTIVE SILYLATIONS OF SUBSTRATES NATIONAL INSTITUTES OF HEALTH, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, U.S. GOVERNMENT 2009-12-17 — — US disclosed
US-20070276138-A1 Modulators of peroxisome proliferator activated receptors BROOKS DAWN A 2007-11-29 — — US disclosed
WO-2007082026-A2 CATALYTIC ENANTIOSELECTIVE SILYLATIONS OF SUBSTRATES THE TRUSTEES OF BOSTON COLLEGE (US) 2007-07-19 — — WO disclosed
US-7192982-B2 Modulators of peroxisome proliferator activated receptors LIGAND PHARMACEUTICALS, INC. (US) 2007-03-20 — — US disclosed
US-20050020684-A1 Modulators of peroxisome proliferator activated receptors ELI LILLY AND COMPANY 2005-01-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140005213-A1 TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS PIM1, PIM2, PIM3 NPY1R 898/4885NPY2R 1297/4885NPY4R 1585/4885
US-20090312559-A1 CATALYTIC ENANTIOSELECTIVE SILYLATIONS OF SUBSTRATES LSS, COASY, CYP51A1 NPY1R 4820/4885NPY2R 4702/4885NPY4R 4815/4885
US-20050020684-A1 Modulators of peroxisome proliferator activated receptors NCOA4, PPARG, PPARA NPY1R 508/4885NPY2R 227/4885NPY4R 47/4885
US-20070276138-A1 Modulators of peroxisome proliferator activated receptors PPARG, NCOA4, PPARA NPY1R 574/4885NPY2R 303/4885NPY4R 60/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.