Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 19/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 13/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377809 | 0.89 | FFAR1 (0.40) | FFAR1FFAR4 | |
| SCHEMBL5381548 | 0.89 | FFAR1 (0.59) | FFAR1FFAR4PTGER4PTGER3AKR1B1 | |
| SCHEMBL5386412 | 0.85 | FFAR1 (0.51) | FFAR1FFAR4PTGER4PTGER3AKR1B1 | |
| SCHEMBL5381983 | 0.84 | FFAR1 (0.53) | FFAR1FFAR4PTGER4PTGER3AKR1B1 | |
| SCHEMBL5387593 | 0.82 | FFAR1 (0.50) | FFAR1FFAR4PTGER4PTGER3AKR1B1 | |
| SCHEMBL5391903 | 0.82 | FFAR1 (0.50) | FFAR1FFAR4PTGER4PTGER3AKR1B1 | |
| SCHEMBL5378986 | 0.82 | FFAR1 (0.47) | FFAR1FFAR4AKR1B1 | |
| SCHEMBL5376735 | 0.82 | FFAR1 (0.49) | FFAR1FFAR4PTGER4PTGER3AKR1B1 | |
| SCHEMBL5397800 | 0.81 | FFAR1 (0.51) | FFAR1FFAR4PTGER4PTGER3 | |
| SCHEMBL5377160 | 0.81 | FFAR1 (0.46) | FFAR1FFAR4AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |