Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31584017 | 0.88 | PTGDR2 (0.47) | TSHRRECQLALDH1A1POLBPTGDR2 | |
| SCHEMBL2820258 | 0.82 | NPBWR1 (0.41) | ALDH1A1PTGDR2BRD4 | |
| SCHEMBL23400358 | 0.82 | TSHR (0.46) | TSHRMAPK14RECQLCYP19A1ALDH1A1 | |
| SCHEMBL21332896 | 0.78 | TSHR (0.53) | TSHRRECQLALDH1A1POLBPTGDR2 | |
| SCHEMBL7592930 | 0.77 | ALDH1A1 (0.52) | TSHRMAPK14RECQLCYP19A1ALDH1A1 | |
| SCHEMBL26042 | 0.76 | NR4A3 (0.54) | MAPK14ALDH1A1POLB | |
| SCHEMBL5377123 | 0.75 | TSHR (0.43) | TSHRMAPK14RECQLCYP19A1ALDH1A1 | |
| SCHEMBL5381957 | 0.74 | RECQL (0.46) | TSHRRECQLCYP19A1ALDH1A1HSD17B10 | |
| SCHEMBL25342354 | 0.73 | ALDH1A1 (0.48) | TSHRALDH1A1HTTHSD17B10 | |
| SCHEMBL5382860 | 0.73 | SMN1; SMN2 (0.58) | TSHRMAPK14CYP19A1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |