Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.56 |
| ▸ | HTR2C | P28335 | 12/20 | 0.56 |
| ▸ | EBP | Q15125 | 1/20 | 0.51 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5380900 | 1.00 | HTR2A (0.56) | HTR2AHTR2CEBPDHCR7CYP3A4 | |
| SCHEMBL5380893 | 1.00 | HTR2A (0.56) | HTR2AHTR2CEBPDHCR7CYP3A4 | |
| Hydrochloric Acid SCHEMBL5379273 | 0.99 | HTR2A (0.55) | HTR2AHTR2CEBPDHCR7CYP3A4 | |
| Hydrochloric Acid SCHEMBL5379281 | 0.99 | HTR2A (0.55) | HTR2AHTR2CEBPDHCR7CYP3A4 | |
| Hydrochloric Acid SCHEMBL5379269 | 0.99 | HTR2A (0.55) | HTR2AHTR2CEBPDHCR7CYP3A4 | |
| SCHEMBL5419262 | 0.89 | HTR2A (0.57) | HTR2AHTR2CL3MBTL1ALDH1A1GAA | |
| SCHEMBL5419273 | 0.89 | HTR2A (0.57) | HTR2AHTR2CL3MBTL1ALDH1A1GAA | |
| SCHEMBL5419259 | 0.89 | HTR2A (0.57) | HTR2AHTR2CL3MBTL1ALDH1A1GAA | |
| SCHEMBL5379282 | 0.89 | HTR2A (0.56) | HTR2AHTR2CL3MBTL1ALDH1A1GAA | |
| SCHEMBL5379277 | 0.89 | HTR2A (0.56) | HTR2AHTR2CL3MBTL1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276607-B2 | 5-HT7 receptor antagonists | MERCK SHARP & DOHME LIMITED (GB) | 2007-10-02 | — | — | US | claimed |
| US-20050080077-A1 | 5-ht7 receptor antagonists | MERCK SHARP & DOHME LTD. (GB) | 2005-04-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080077-A1 | 5-ht7 receptor antagonists | HTR7, HTR2B, HTR1A | HTR2A 13/4885HTR2C 4/4885EBP 3013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.