Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.58 |
| ▸ | TTK | P33981 | 3/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | ITK | Q08881 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.51 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.51 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5783999 | 0.91 | AURKA (0.57) | AURKATTKMAPK8ITKMAPK1 | |
| SCHEMBL5372788 | 0.88 | AURKA (0.68) | AURKATTKMAPK8ITKMAPK1 | |
| SCHEMBL5381231 | 0.88 | AURKA (0.59) | AURKATTKITKMAPK1MAP2K4 | |
| SCHEMBL5383159 | 0.84 | MAPK1 (0.54) | AURKATTKITKMAPK1MAP2K4 | |
| SCHEMBL5424790 | 0.84 | NPC1 (0.54) | AURKATTKMAPK8ITKMAPK1 | |
| SCHEMBL5386918 | 0.83 | TTK (0.56) | AURKATTKMAPK8ITKMAPK1 | |
| SCHEMBL2859988 | 0.82 | ITK (0.57) | AURKATTKMAPK8ITKMAPK1 | |
| SCHEMBL5381326 | 0.80 | HTR3A (0.51) | AURKATTK | |
| SCHEMBL5800969 | 0.80 | TTK (0.59) | AURKATTKITKMAPK1MAP2K4 | |
| SCHEMBL5785886 | 0.79 | AURKA (0.66) | AURKATTKMAPK8ITKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211594-B2 | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-05-01 | — | — | US | disclosed |