Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 12/20 | 0.47 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10843644 | 0.84 | XDH (0.54) | CDC7KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL5377577 | 0.80 | CDC7 (0.49) | CDC7PKN1PKN2CDK9CDK2 | |
| SCHEMBL7395689 | 0.79 | MAPK14 (0.48) | CDC7GSK3BMAPK13MAPK1MAPK12 | |
| SCHEMBL5377972 | 0.79 | GSK3B (0.56) | CDC7PKN1PKN2CDK9CDK2 | |
| SCHEMBL10840691 | 0.78 | CDC7 (0.44) | CDC7PKN1PKN2CDK9CDK2 | |
| SCHEMBL5377688 | 0.75 | GSK3B (0.59) | CDC7PKN1PKN2CDK9CDK2 | |
| SCHEMBL5381545 | 0.75 | CDC7 (0.59) | CDC7PKN1PKN2CDK2GSK3B | |
| SCHEMBL5038081 | 0.75 | MAPK14 (0.44) | CDC7PKN1PKN2CDK9CDK2 | |
| SCHEMBL5399975 | 0.75 | CDC7 (0.48) | CDC7PKN1PKN2CDK9CDK2 | |
| SCHEMBL5384156 | 0.75 | CDC7 (0.44) | CDC7PKN1PKN2CDK9CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321295-B1 | 4-(PYRIDIN-4-YL)-1H-[1,3,5]TRIAZIN-2-ONE DERIVATIVES AS GSK3-BETA INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-12-21 | — | — | EP | disclosed |
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |