SCHEMBL5381328

SCHEMBL5381328

COC(Cc1ccc(Cc2c(C)cc(C)nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1)OC

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ SLC5A2 P31639 20/20 0.57
▸ SLC5A1 P13866 19/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4359584 0.88 SLC5A2 (0.68) SLC5A2SLC5A1
SCHEMBL4350692 0.88 SLC5A2 (0.67) SLC5A2SLC5A1
SCHEMBL4358723 0.87 SLC5A2 (0.58) SLC5A2SLC5A1
SCHEMBL5381324 0.84 SLC5A2 (0.53) SLC5A2SLC5A1
SCHEMBL3185909 0.83 SLC5A2 (0.55) SLC5A2SLC5A1
SCHEMBL4359089 0.80 SLC5A2 (0.68) SLC5A2SLC5A1
SCHEMBL22716935 0.80 SLC5A2 (0.68) SLC5A2SLC5A1
SCHEMBL29572195 0.80 SLC5A2 (0.68) SLC5A2SLC5A1
SCHEMBL5381393 0.77 SLC5A2 (0.55) SLC5A2SLC5A1
SCHEMBL4291085 0.75 SLC5A2 (0.49) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7271153-B2 Treating diseases associated with hyperglycemia such as diabetes; SGLT2 (sodium/glucose cotransporter 2) inhibitor; 3-(4-Ethylbenzyl)-2-(beta-D-glucopyranosyloxy)-4,6-dimethyl-pyridine for example KISSEI PHARMACEUTICAL CO., LTD. (JP) 2007-09-18 — — US disclosed
US-20050049203-A1 Nitrogenous heterocyclic derivative, medicinal composition containing the same, medical use thereof, and intermediate therefor KISSEI PHARMACEUTICAL CO., LTD. (JP) 2005-03-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050049203-A1 Nitrogenous heterocyclic derivative, medicinal composition containing the same, medical use thereof, and intermediate therefor GPR119, NPR3, SLC5A2 SLC5A2 3/4885SLC5A1 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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