Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 13/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.55 |
| ▸ | RAF1 | P04049 | 9/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 4/20 | 0.52 |
| ▸ | GCGR | P47871 | 4/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5382372 | 0.85 | MAPK13 (0.56) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5388030 | 0.84 | GSK3B (0.50) | MAPK13MAPK12MAPK11MAPK14GSK3B | |
| SCHEMBL5390448 | 0.83 | MAPK13 (0.54) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5380270 | 0.81 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5381411 | 0.80 | MAPK13 (0.56) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5380491 | 0.77 | MAPK13 (0.60) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5390319 | 0.77 | MAPK13 (0.60) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5383500 | 0.77 | MAPK13 (0.60) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL1501739 | 0.74 | FNTA (0.53) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL10981478 | 0.73 | GSK3B (0.46) | MAPK14GSK3BCCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |