Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BUB1 | O43683 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5381409 | 0.84 | MAPK13 (0.55) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5388031 | 0.80 | CYP1A2 (0.59) | GSK3BKDM4ESMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL14942695 | 0.78 | ALKBH3 (0.45) | KDM4ESMN1; SMN2HPGDALDH1A1MAPK1 | |
| SCHEMBL10981478 | 0.73 | GSK3B (0.46) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5380586 | 0.72 | GSK3B (0.55) | GSK3BSMN1; SMN2ALDH1A1HTTRAB9A | |
| SCHEMBL5382372 | 0.71 | MAPK13 (0.56) | GSK3BMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5400580 | 0.71 | GSK3B (0.57) | GSK3BPLA2G7MAPK13MAPK12MAPK11 | |
| SCHEMBL1387860 | 0.70 | KDM4E (0.83) | KDM4ESMN1; SMN2HPGDALDH1A1MAPK13 | |
| SCHEMBL5382895 | 0.70 | GSK3B (0.56) | GSK3BPLA2G7MAPK13MAPK12MAPK11 | |
| SCHEMBL5380270 | 0.70 | MAPK13 (0.51) | GSK3BMAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |