Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | GCGR | P47871 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5380589 | 0.94 | GSK3B (0.56) | GSK3BMAPK14MAPK13GCGRMAPK12 | |
| SCHEMBL5400586 | 0.92 | GSK3B (0.58) | GSK3BMAPK14MAPK13GCGRMAPK12 | |
| SCHEMBL5392069 | 0.85 | GSK3B (0.59) | GSK3BMAPK14MAPK13GCGRMAPK12 | |
| SCHEMBL5382895 | 0.82 | GSK3B (0.56) | GSK3BMAPK14MAPK13GCGRMAPK12 | |
| SCHEMBL5390452 | 0.79 | MAPK13 (0.55) | GSK3BMAPK14MAPK13GCGRMAPK12 | |
| SCHEMBL5380586 | 0.77 | GSK3B (0.55) | GSK3BMAPK14MAPK13GCGRMAPK12 | |
| SCHEMBL5400580 | 0.76 | GSK3B (0.57) | GSK3BMAPK14MAPK13GCGRMAPK12 | |
| SCHEMBL6932122 | 0.76 | MAPK14 (0.61) | GSK3BMAPK14MAPK13GCGRMAPK12 | |
| SCHEMBL5380275 | 0.74 | POLB (0.56) | GSK3BMAPK14MAPK13GCGRMAPK12 | |
| SCHEMBL5392064 | 0.73 | GSK3B (0.59) | GSK3BMAPK14MAPK13GCGRMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |