Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.45 |
| ▸ | CCR3 | P51677 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365880 | 0.85 | SLC6A2 (0.41) | SLC6A2SLC6A4HDAC6TMEM97CCR3 | |
| SCHEMBL5365936 | 0.84 | DRD2 (0.47) | SLC6A2SLC6A4CCR3LMNASMN1; SMN2 | |
| SCHEMBL5377672 | 0.74 | HDAC6 (0.49) | SLC6A2SLC6A4HDAC6MAPK1 | |
| SCHEMBL5369137 | 0.74 | GAA (0.47) | HDAC6SMN1; SMN2 | |
| SCHEMBL5375990 | 0.74 | GAA (0.51) | HDAC6 | |
| SCHEMBL5378067 | 0.73 | SLC6A2 (0.45) | SLC6A2SLC6A4HDAC6TMEM97CCR3 | |
| SCHEMBL5371447 | 0.73 | HDAC6 (0.55) | SLC6A2SLC6A4HDAC6 | |
| SCHEMBL5374200 | 0.73 | GAA (0.45) | HDAC6 | |
| SCHEMBL7220278 | 0.72 | GAA (0.45) | HDAC6 | |
| SCHEMBL5377677 | 0.71 | GAA (0.50) | HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189739-B2 | Compounds and methods to treat cardiac failure and other disorders | SCIOS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | disclosed |
| US-6589954-B1 | Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful | SCIOS, INC. | 2003-07-08 | — | — | US | disclosed |
| EP-1080078-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061426-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 1999-12-02 | — | — | WO | disclosed |