Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365936 | 0.89 | DRD2 (0.47) | SLC6A2SLC6A4CYP2C9CYP2C19MAPK14 | |
| SCHEMBL5383002 | 0.85 | SLC6A2 (0.51) | SLC6A2SLC6A4HDAC6CCR3TMEM97 | |
| SCHEMBL7379172 | 0.75 | SLC6A2 (0.41) | SLC6A2SLC6A4CYP2C9CYP2C19HTR2B | |
| SCHEMBL7220084 | 0.68 | HTR7 (0.46) | SLC6A2SLC6A4HDAC6 | |
| SCHEMBL7369230 | 0.66 | MEN1 (0.47) | SLC6A2SLC6A4CYP2C9CYP2C19MAPK14 | |
| SCHEMBL5371447 | 0.66 | HDAC6 (0.55) | SLC6A2SLC6A4HDAC6ACHE | |
| SCHEMBL5377672 | 0.65 | HDAC6 (0.49) | SLC6A2SLC6A4HDAC6ACHENPC1 | |
| SCHEMBL7375682 | 0.65 | MEN1 (0.50) | CYP2C9HTR2BACHENPC1RAB9A | |
| SCHEMBL5369137 | 0.65 | GAA (0.47) | HDAC6ACHE | |
| SCHEMBL5378067 | 0.65 | SLC6A2 (0.45) | SLC6A2SLC6A4HDAC6CCR3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189739-B2 | Compounds and methods to treat cardiac failure and other disorders | SCIOS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | disclosed |
| US-6589954-B1 | Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful | SCIOS, INC. | 2003-07-08 | — | — | US | disclosed |