Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 7/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377275 | 0.89 | RAB9A (0.39) | RAB9AMAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL7488315 | 0.81 | KDM4E (0.43) | RAB9AMAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL6157057 | 0.80 | RAB9A (0.52) | RAB9AMAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL5382459 | 0.78 | KDM4E (0.40) | RAB9AMAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL5371916 | 0.74 | PDE10A (0.48) | RAB9AMAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL7537573 | 0.73 | FFAR1 (0.34) | PDE10A | |
| Hydrochloric Acid SCHEMBL6157540 | 0.73 | PDE10A (0.47) | RAB9AMAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL6157321 | 0.72 | KDM4E (0.51) | RAB9AMAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL5384818 | 0.67 | PDE10A (0.47) | RAB9AMAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL9570224 | 0.67 | PDE10A (0.50) | RAB9AMAPTPOLBSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |