Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.67 |
| ▸ | XDH | P47989 | 1/20 | 0.61 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 2/20 | 0.47 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | TYMP | P19971 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5383544 | 0.85 | GSK3B (0.68) | GSK3BXDHCDC7PKN1PKN2 | |
| SCHEMBL5381549 | 0.81 | GSK3B (1.00) | GSK3BXDHCDC7MAPK14MAPK13 | |
| SCHEMBL5377580 | 0.80 | GSK3B (0.87) | GSK3BXDHCDC7CLK4 | |
| SCHEMBL5383553 | 0.80 | GSK3B (0.72) | GSK3BXDHMAPK14 | |
| SCHEMBL7391408 | 0.80 | GSK3B (0.72) | GSK3BXDHCDC7 | |
| SCHEMBL5392045 | 0.80 | GSK3B (0.72) | GSK3BXDHCDC7MAPK14MAPK13 | |
| SCHEMBL5388174 | 0.80 | CDC7 (0.56) | XDHPIN1CDC7PKN1PKN2 | |
| SCHEMBL5391583 | 0.77 | GSK3B (0.67) | GSK3BPIN1CDC7MAPK14MAPK13 | |
| SCHEMBL5376063 | 0.77 | GSK3B (0.76) | GSK3BCDC7 | |
| SCHEMBL2881243 | 0.76 | XDH (1.00) | XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |