Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5375436 | 0.84 | GSK3B (0.48) | GSK3BHCAR2MAPKAPK2DAOGPR84 | |
| SCHEMBL5387928 | 0.84 | GSK3B (0.65) | GSK3BHCAR2CDC7DAOMAPK13 | |
| SCHEMBL5382154 | 0.83 | GSK3B (0.47) | GSK3BHCAR2MAPKAPK2DAOIDO1 | |
| SCHEMBL5383593 | 0.81 | GSK3B (0.72) | GSK3BHCAR2DAOMAPK13MAPK12 | |
| SCHEMBL5386067 | 0.78 | GSK3B (0.51) | GSK3BHCAR2DAO | |
| SCHEMBL5390682 | 0.76 | GSK3B (0.64) | GSK3BCDC7DAOTUBB4ATUBB | |
| SCHEMBL5390574 | 0.76 | GSK3B (0.49) | GSK3BHCAR2DAOTUBB4ATUBB | |
| SCHEMBL5381446 | 0.70 | GSK3B (0.47) | GSK3BMAPKAPK2CDC7ROCK2MAP4K4 | |
| SCHEMBL5376093 | 0.70 | GSK3B (0.63) | GSK3BMAPKAPK2CDC7CDK2DAO | |
| SCHEMBL12318506 | 0.69 | NPC1 (0.58) | GSK3BMAPKAPK2CDC7ROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |