Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 2/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10373408 | 0.78 | KDM4E (0.48) | KMT2ARORCCYP1A2CA12CA1 | |
| SCHEMBL11377551 | 0.76 | KDM4E (0.46) | RORCCYP1A2CFTRCA12CA1 | |
| SCHEMBL29076952 | 0.75 | KDM4E (0.51) | MEN1KMT2ACYP1A2ALDH1A1KDM4E | |
| SCHEMBL29440766 | 0.74 | ENPP3 (0.45) | MEN1KMT2ARORCCYP1A2CFTR | |
| SCHEMBL22734645 | 0.74 | ENPP3 (0.45) | MEN1KMT2ARORCCYP1A2CFTR | |
| SCHEMBL6733600 | 0.74 | KDM4E (0.45) | KMT2ARORCCA12CA1CA2 | |
| SCHEMBL16505879 | 0.74 | KMT2A (0.45) | MEN1KMT2ACYP1A2TRPV4ALDH1A1 | |
| SCHEMBL165727 | 0.74 | SMN1; SMN2 (0.48) | MEN1KMT2ACYP1A2CFTRTRPV4 | |
| SCHEMBL28590532 | 0.74 | CYP1A2 (0.50) | MEN1KMT2ACYP1A2CA12CA1 | |
| SCHEMBL29799178 | 0.74 | CYP1A2 (0.50) | MEN1KMT2ACYP1A2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166852-B1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | HELICON THERAPEUTICS INC (US) | 2012-02-08 | — | — | EP | disclosed |