Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CDC25A | P30304 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370115 | 0.78 | CYP1A2 (0.44) | TSHRALDH1A1HSD17B10CA1CA2 | |
| Terephthalic Acid SCHEMBL3735419 | 0.76 | TSHR (0.43) | TSHRTP53CES2CES1SRD5A2 | |
| Terephthalic Acid SCHEMBL5393223 | 0.73 | ALDH1A1 (0.47) | TSHRTP53ALDH1A1MEN1KMT2A | |
| Ethylene Glycol SCHEMBL3016260 | 0.72 | CYP1A2 (0.38) | TSHRALDH1A1CA1CA2CA12 | |
| SCHEMBL7165102 | 0.69 | ALDH1A1 (0.50) | TSHRTP53SRD5A2ALDH1A1HSD17B10 | |
| Terephthalic Acid SCHEMBL7603708 | 0.68 | TSHR (0.57) | TSHRTP53CES2CES1SRD5A2 | |
| Terephthalic Acid SCHEMBL8662457 | 0.68 | TSHR (0.63) | TSHRTP53CES2CES1SRD5A2 | |
| SCHEMBL7697258 | 0.68 | CYP1A2 (0.39) | TSHRALDH1A1HSD17B10KDM4EALOX15 | |
| SCHEMBL196225 | 0.68 | CYP1A2 (0.41) | TSHRALDH1A1CDC25ACDC25BHSD17B10 | |
| SCHEMBL967549 | 0.66 | CYP1A2 (0.44) | TSHRALDH1A1CDC25ACDC25BHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538183-B1 | THERMOPLASTIC FILM, THERMOPLASTIC RESIN COMPOSITION, AND PHYLLOSILICATE | TEIJIN LTD (JP) | 2007-10-31 | — | — | EP | disclosed |
| US-7189782-B2 | Thermoplastic film, thermoplastic resin composition, and phyllosilicate | TEIJIN LIMITED (JP) | 2007-03-13 | — | — | US | disclosed |
| EP-1538183-A1 | THERMOPLASTIC FILM, THERMOPLASTIC RESIN COMPOSITION, AND PHYLLOSILICATE | TEIJIN LIMITED (JP) | 2005-06-08 | — | — | EP | disclosed |
| US-20050089698-A1 | Thermoplastic film, thermoplastic resin composition, and phyllosilicate | TEIJIN LIMITED (JP) | 2005-04-28 | — | — | US | disclosed |