Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.56 |
| ▸ | XDH | P47989 | 2/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | PRKACA | P17612 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | ITK | Q08881 | 1/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5385642 | 0.80 | AURKA (0.51) | ADORA1AURKBCDC7AURKATTK | |
| SCHEMBL5383599 | 0.79 | ADORA2A (0.62) | GSK3BXDHAURKBCDC7ROCK2 | |
| SCHEMBL5380557 | 0.75 | XDH (0.85) | GSK3BXDHAURKBCDC7ROCK2 | |
| SCHEMBL10840696 | 0.75 | GSK3B (0.60) | GSK3BXDHAURKBCDC7ROCK2 | |
| SCHEMBL14514019 | 0.74 | GSK3B (0.59) | GSK3BXDHAURKBCDC7ROCK2 | |
| SCHEMBL24867395 | 0.73 | F2 (0.58) | ADORA1AURKBAURKATTKITK | |
| SCHEMBL3825028 | 0.72 | XDH (0.51) | GSK3BXDHAURKBCDC7ROCK2 | |
| SCHEMBL5381549 | 0.72 | GSK3B (1.00) | GSK3BXDHCDC7DBF4ALDH1A1 | |
| SCHEMBL14514005 | 0.72 | GSK3B (0.52) | GSK3BXDHAURKBCDC7ROCK2 | |
| SCHEMBL5375274 | 0.72 | XDH (0.55) | GSK3BXDHAURKBCDC7ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |