Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | HPGD | P15428 | 7/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5385765 | 1.00 | KDM4E (0.46) | KDM4EALDH1A1MAPTHPGDGAA | |
| SCHEMBL5392736 | 0.88 | ALDH1A1 (0.51) | KDM4EALDH1A1MAPTHPGDGAA | |
| SCHEMBL5392742 | 0.88 | ALDH1A1 (0.51) | KDM4EALDH1A1MAPTHPGDGAA | |
| SCHEMBL16971191 | 0.85 | NOTUM (0.42) | KDM4EALDH1A1MAPTHPGDGAA | |
| SCHEMBL16971192 | 0.85 | NOTUM (0.42) | KDM4EALDH1A1MAPTHPGDGAA | |
| SCHEMBL1496056 | 0.83 | LCK (0.42) | KDM4EALDH1A1MAPTATMNPC1 | |
| SCHEMBL1496059 | 0.83 | LCK (0.42) | KDM4EALDH1A1MAPTATMNPC1 | |
| SCHEMBL4206326 | 0.82 | CYP3A4 (0.41) | KDM4EALDH1A1MAPTHPGDGAA | |
| SCHEMBL4206316 | 0.82 | CYP3A4 (0.41) | KDM4EALDH1A1MAPTHPGDGAA | |
| SCHEMBL20171888 | 0.78 | KDM4E (0.44) | KDM4EALDH1A1MAPTHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49698-E1 | Substituted dihydroquinazolines | AIC246 AG & CO. KG (DE) | 2023-10-17 | — | — | US | disclosed |
| US-RE49698-E1 | Substituted dihydroquinazolines | AIC246 AG & CO. KG (DE) | 2023-10-17 | — | — | US | disclosed |
| US-RE49698-E1 | Substituted dihydroquinazolines | AIC246 AG & CO. KG (DE) | 2023-10-17 | — | — | US | disclosed |
| US-RE46791-E1 | Substituted dihydroquinazolines | AICURIS ANTI-INFECTIVE CURES GMBH (DE) | 2018-04-17 | — | — | US | disclosed |
| US-RE46791-E1 | Substituted dihydroquinazolines | AICURIS ANTI-INFECTIVE CURES GMBH (DE) | 2018-04-17 | — | — | US | disclosed |
| US-RE46791-E1 | Substituted dihydroquinazolines | AICURIS ANTI-INFECTIVE CURES GMBH (DE) | 2018-04-17 | — | — | US | disclosed |
| US-8513255-B2 | Substituted dihydroquinazolines | AiCuris GmbH + Co. KG. (DE) | 2013-08-20 | — | — | US | disclosed |
| US-8513255-B2 | Substituted dihydroquinazolines | AiCuris GmbH + Co. KG. (DE) | 2013-08-20 | — | — | US | disclosed |
| US-8513255-B2 | Substituted dihydroquinazolines | AiCuris GmbH + Co. KG. (DE) | 2013-08-20 | — | — | US | disclosed |
| US-20070191387-A1 | Substituted dihydroquinazolines | BAYER HEALTHCARE AG (DE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191387-A1 | Substituted dihydroquinazolines | BAYER HEALTHCARE AG (DE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191387-A1 | Substituted dihydroquinazolines | BAYER HEALTHCARE AG (DE) | 2007-08-16 | — | — | US | disclosed |
| US-7196086-B2 | Substituted dihydroquinazolines | BAYER HEALTHCARE AG (DE) | 2007-03-27 | — | — | US | disclosed |
| US-7196086-B2 | Substituted dihydroquinazolines | BAYER HEALTHCARE AG (DE) | 2007-03-27 | — | — | US | disclosed |
| US-7196086-B2 | Substituted dihydroquinazolines | BAYER HEALTHCARE AG (DE) | 2007-03-27 | — | — | US | disclosed |
| EP-1622880-B1 | SUBSTITUTED DIHYDROCHINAZOLINES HAVING ANTIVIRAL PROPERTIES | BAYER HEALTHCARE AG (DE) | 2007-02-28 | — | — | EP | disclosed |
| US-20050065160-A1 | Substituted dihydroquinazolines | BAYER HEALTHCARE AG (DE) | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065160-A1 | Substituted dihydroquinazolines | TPMT, TYMP, DPYD | KDM4E 3034/4885ALDH1A1 2784/4885MAPT 1906/4885 |
| US-20070191387-A1 | Substituted dihydroquinazolines | TPMT, TYMP, DPYD | KDM4E 3034/4885ALDH1A1 2784/4885MAPT 1906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.