Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | KHK | P50053 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.44 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.44 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5389772 | 0.91 | MAPT (0.47) | SMN1; SMN2MAPTNAMPTKHKALDH1A1 | |
| SCHEMBL25386656 | 0.82 | KDR (0.45) | SMN1; SMN2TP53MAPTJAK2FLT3 | |
| SCHEMBL5823587 | 0.80 | JAK2 (0.43) | NAMPTJAK2FLT3BRAFTDP1 | |
| SCHEMBL5387423 | 0.79 | AURKA (0.42) | SMN1; SMN2TP53MAPTKDM4EJAK2 | |
| SCHEMBL26938050 | 0.79 | GALR2 (0.48) | SMN1; SMN2MAPTNAMPTALDH1A1JAK2 | |
| SCHEMBL5402668 | 0.78 | AURKA (0.48) | SMN1; SMN2TP53MAPTALDH1A1KDM4E | |
| SCHEMBL5820251 | 0.78 | CYP1A2 (0.45) | SMN1; SMN2MAPTNAMPTALDH1A1KDM4E | |
| SCHEMBL5820813 | 0.78 | NAMPT (0.47) | MAPTNAMPTALDH1A1KDM4EBRAF | |
| SCHEMBL29091968 | 0.78 | MAPT (0.49) | TP53MAPTALDH1A1KDM4EJAK2 | |
| SCHEMBL5823039 | 0.77 | AURKA (0.50) | NAMPTALDH1A1KDM4EBRAFTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276501-B2 | 6-(4-substituted-anilino)pyrimidine derivatives, method for preparation thereof and antiviral pharmaceutical composition comprising the same | B & C BIOPHARM (KR) | 2007-10-02 | — | — | US | disclosed |
| EP-1490358-A4 | 6-(4-SUBSTITUTED-ANILINO)PYRIMIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | B & C BIOPHARM (KR) | 2006-04-12 | — | — | EP | disclosed |
| US-20050222150-A1 | 6-(4-substituted-anilino)pyrimidine derivates, method for preparation thereof and antiviral pharmaceutical composition comprising the same | B & C BIOPHARM (KR) | 2005-10-06 | — | — | US | disclosed |
| EP-1490358-A1 | 6-(4-SUBSTITUTED-ANILINO)PYRIMIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | B & C Biopharm (KR) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084953-A1 | 6-(4-SUBSTITUTED-ANILINO)PYRIMIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | B & C BIOPHARM (KR) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222150-A1 | 6-(4-substituted-anilino)pyrimidine derivates, method for preparation thereof and antiviral pharmaceutical composition comprising the same | HAVCR2, NUDT1, GART | SMN1; SMN2 4007/4885TP53 1589/4885HTT 4451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.