Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5386406 | 0.99 | HSD17B10 (0.45) | HSD17B10PKN1PKN2CDC7MEN1 | |
| SCHEMBL5381026 | 0.86 | AR (0.44) | HSD17B10CDC7MEN1KMT2ACDK2 | |
| SCHEMBL7978699 | 0.81 | MAPT (0.52) | HSD17B10CDC7MEN1CYP1A2CYP2C19 | |
| SCHEMBL7989788 | 0.79 | ALDH1A1 (0.58) | HSD17B10MEN1CYP2C19KMT2AHPGD | |
| SCHEMBL7990353 | 0.78 | KDM4E (0.52) | HSD17B10CYP1A2HPGDMAPK1KDM4E | |
| SCHEMBL7990765 | 0.78 | CDC7 (0.39) | PKN1PKN2CDC7CDK9DYRK3 | |
| SCHEMBL7978276 | 0.77 | HRH4 (0.49) | — | |
| SCHEMBL5380085 | 0.77 | HSD17B10 (0.77) | HSD17B10CDC7MEN1CYP1A2CYP2C19 | |
| SCHEMBL7989669 | 0.76 | KCNH2 (0.35) | CDC7 | |
| SCHEMBL7978711 | 0.76 | POLB (0.46) | HSD17B10GSK3BKDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |