SCHEMBL5386493

SCHEMBL5386493

CC(C)c1cc(Cl)c(O)cc1Cl

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.57
TSHR P16473 5/20 0.52
HSD17B10 Q99714 4/20 0.52
HPGD P15428 3/20 0.52
GABRA1 P14867 6/20 0.48
GABRB1 P18505 4/20 0.48
ALOX15 P16050 1/20 0.42
ALOX12 P18054 1/20 0.42
CYP3A4 P08684 3/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
ALDH1A1 P00352 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
GABRB2 P47870 4/20 0.40
SLC6A2 P23975 2/20 0.40
HTR2B P41595 2/20 0.40
TRPA1 O75762 1/20 0.40
CHRM1 P11229 1/20 0.40
ADRA1A P35348 1/20 0.40
HTT P42858 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20259866 0.91 TSHR (0.52) LMNATSHRHSD17B10HPGDGABRA1
SCHEMBL15631282 0.88 LMNA (0.54) LMNATSHRHSD17B10HPGDGABRA1
SCHEMBL21686455 0.86 LMNA (0.69) LMNATSHRHSD17B10HPGDGABRA1
SCHEMBL16736820 0.86 LMNA (0.69) LMNATSHRHPGDGABRA1GABRB1
SCHEMBL11862411 0.84 LMNA (0.52) LMNATSHRHPGDGABRA1GABRB1
SCHEMBL10702604 0.83 LMNA (0.72) LMNATSHRHSD17B10HPGDGABRA1
SCHEMBL23420935 0.80 LMNA (0.47) LMNATSHRHSD17B10HPGDGABRA1
SCHEMBL22560952 0.80 LMNA (0.47) LMNATSHRHSD17B10HPGDGABRA1
SCHEMBL13818324 0.79 LMNA (0.48) LMNATSHRHSD17B10HPGDGABRA1
SCHEMBL29369045 0.77 LMNA (0.59) LMNAHSD17B10HPGDGABRA1GABRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7202359-B2 Azaoxa heterocyclic compound and method of preparing the same CHANG CHUN PLASTICS CO., LTD. (TW) 2007-04-10 US disclosed
US-20050085634-A1 Azaoxa heterocyclic compound and method of preparing the same CHANG CHUN PLASTICS CO., LTD. (TW) 2005-04-21 US disclosed
US-20040254305-A1 Epoxy resin composition for photosemiconductor package CHANG CHUN PLASTIC CO., LTD. (TW) 2004-12-16 US disclosed
US-20040068084-A1 Azaoxa heterocyclic compound and method of preparing the same CHANG CHUN PLASTICS CO., LTD. (TW) 2004-04-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040068084-A1 Azaoxa heterocyclic compound and method of preparing the same AOX1, KDM1A, BMI1 LMNA 2897/4885TSHR 4548/4885HSD17B10 2457/4885
US-20050085634-A1 Azaoxa heterocyclic compound and method of preparing the same AOX1, KDM1A, BMI1 LMNA 3143/4885TSHR 4491/4885HSD17B10 2547/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.