Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Elobixibat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A2 known ✓ | Q12908 | 9/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.59 |
| ▸ | CTSD | P07339 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Elobixibat SCHEMBL29351648 | 1.00 | NR1H4 (0.59) | NR1H4SLC10A2CTSD | |
| Elobixibat SCHEMBL5940599 | 1.00 | NR1H4 (0.59) | NR1H4SLC10A2CTSD | |
| Elobixibat SCHEMBL1183501 | 1.00 | NR1H4 (0.59) | NR1H4SLC10A2CTSD | |
| Elobixibat SCHEMBL29974592 | 0.99 | NR1H4 (0.59) | NR1H4SLC10A2CTSD | |
| SCHEMBL14559659 | 0.98 | NR1H4 (0.57) | NR1H4SLC10A2CTSD | |
| SCHEMBL5224917 | 0.98 | NR1H4 (0.59) | NR1H4SLC10A2CTSD | |
| SCHEMBL919390 | 0.98 | NR1H4 (0.59) | NR1H4SLC10A2CTSD | |
| SCHEMBL22484941 | 0.97 | NR1H4 (0.57) | NR1H4SLC10A2CTSD | |
| SCHEMBL22485252 | 0.97 | NR1H4 (0.56) | NR1H4SLC10A2CTSD | |
| SCHEMBL1183058 | 0.96 | NR1H4 (0.65) | NR1H4SLC10A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7192945-B2 | Benzothiazepine derivatives | ASTRAZENECA AB (SE) | 2007-03-20 | — | — | US | disclosed |
| US-20040067933-A1 | Chemical compounds | ELOBIX AB (SE) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067933-A1 | Chemical compounds | SLC10A2, SLC10A1, ABCB11 | SLC10A2 1/4885NR1H4 7/4885CTSD 2456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.