Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.63 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KDM6B | O15054 | 1/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | ASPH | Q12797 | 1/20 | 0.50 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.50 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10839345 | 0.88 | KDM6B (0.55) | SIRT2PKMRPS6KB1AKT1ALDH1A1 | |
| Enfenamic Acid SCHEMBL25191 | 0.86 | KDM6B (0.68) | PKMALDH1A1MAPTHPGDLMNA | |
| Enfenamic Acid SCHEMBL10935569 | 0.85 | KDM6B (0.66) | PKMALDH1A1MAPTHPGDLMNA | |
| SCHEMBL2754257 | 0.84 | HSD17B10 (0.63) | SIRT2RPS6KB1AKT1ALDH1A1HPGD | |
| SCHEMBL30311518 | 0.84 | HSD17B10 (0.63) | SIRT2RPS6KB1AKT1ALDH1A1HPGD | |
| SCHEMBL12608931 | 0.83 | RXFP1 (0.54) | PKMALDH1A1MAPTHPGDLMNA | |
| SCHEMBL3716882 | 0.82 | KDM4C (0.67) | PKMRPS6KB1AKT1KDM6BKDM4C | |
| Enfenamic Acid SCHEMBL10935566 | 0.82 | MAPT (0.53) | PKMALDH1A1MAPTHPGDLMNA | |
| SCHEMBL11454827 | 0.82 | SIRT2 (0.51) | SIRT2PKMALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL11457102 | 0.81 | SIRT2 (0.50) | SIRT2PKMALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253198-B2 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-08-07 | — | — | US | disclosed |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | BACE2, PSEN2, BACE1 | SIRT2 1101/4885PKM 1448/4885RPS6KB1 1209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.