Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | GCGR | P47871 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 2/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378013 | 0.82 | GSK3B (0.68) | GSK3BMAPK14CDC7MAPTHPGD | |
| SCHEMBL5381549 | 0.80 | GSK3B (1.00) | GSK3BMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5377580 | 0.79 | GSK3B (0.87) | GSK3BCDC7DBF4ALDH1A1MAPT | |
| SCHEMBL801881 | 0.79 | GSK3B (0.63) | GSK3BCDC7HPGD | |
| SCHEMBL5388025 | 0.78 | MAPK14 (0.51) | GSK3BMAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL5396525 | 0.76 | GSK3B (0.71) | GSK3BCDC7ALDH1A1MAPTHPGD | |
| SCHEMBL5392045 | 0.74 | GSK3B (0.72) | GSK3BMAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL5383553 | 0.74 | GSK3B (0.72) | GSK3BMAPK14NPC1RAB9AXDH | |
| SCHEMBL7391408 | 0.74 | GSK3B (0.72) | GSK3BALOX5CDC7ALDH1A1MAPT | |
| SCHEMBL5376063 | 0.73 | GSK3B (0.76) | GSK3BCDC7DBF4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |