Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5389371 | 0.82 | SLC34A1 (0.45) | USP2ALDH1A1CYP2C9CASP1CASP7 | |
| SCHEMBL5398740 | 0.77 | GABRG2 (0.44) | USP2ALDH1A1CYP2C9CASP1CASP7 | |
| SCHEMBL5394734 | 0.74 | CYP11B1 (0.42) | USP2ALDH1A1CYP2C9CASP1CASP7 | |
| SCHEMBL5382808 | 0.72 | GABRG2 (0.43) | USP2ALDH1A1CYP2C9CASP1CASP7 | |
| SCHEMBL5395093 | 0.71 | GABRG2 (0.42) | GABRG2GABRB3GABRA5GABRA3NPY5R | |
| SCHEMBL5385380 | 0.68 | GABRG2 (0.51) | TRPA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL12871650 | 0.66 | MAPK14 (0.44) | ALDH1A1SLC34A1 | |
| SCHEMBL20491327 | 0.66 | GABRG2 (0.65) | GABRG2GABRB3GABRA5GABRA3NPY5R | |
| SCHEMBL31395062 | 0.66 | GABRG2 (0.65) | GABRG2GABRB3GABRA5GABRA3NPY5R | |
| SCHEMBL7053828 | 0.65 | NTRK1 (0.45) | USP2ALDH1A1CYP2C9LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271191-B2 | Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of Alzheimer's disease | MERCK SHARP & DOHME LTD. (GB) | 2007-09-18 | — | — | US | disclosed |
| US-20060264474-A1 | Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of alzheimer's disease | MERCK SHARP & DOHME LTD. (GB) | 2006-11-23 | — | — | US | disclosed |
| WO-2004089911-A1 | PYRAZOLE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS USEFUL IN THE TREATMENT OF ALZHEIMER’S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264474-A1 | Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of alzheimer's disease | BACE1, BACE2, PSEN1 | USP2 1710/4885ALDH1A1 926/4885CYP2C9 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.