SCHEMBL7053828

SCHEMBL7053828

Cc1c(-c2ccccc2)nn(C)c1NCc1cccc(C#N)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 1/20 0.45
NTRK3 Q16288 1/20 0.45
NTRK2 Q16620 1/20 0.45
CYP1A2 P05177 9/20 0.45
CYP2C19 P33261 7/20 0.45
ALDH1A1 P00352 6/20 0.45
HSD17B10 Q99714 6/20 0.45
CLK4 Q9HAZ1 5/20 0.45
MAPK1 P28482 5/20 0.45
USP2 O75604 4/20 0.45
GABRG2 P18507 1/20 0.45
GABRB3 P28472 1/20 0.45
GABRA5 P31644 1/20 0.45
GABRA3 P34903 1/20 0.45
CYP3A4 P08684 7/20 0.44
CYP2D6 P10635 7/20 0.44
TSHR P16473 5/20 0.44
KDM4E B2RXH2 3/20 0.44
HPGD P15428 2/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6972135 0.70 MEN1 (0.47) NTRK1NTRK3NTRK2CYP1A2CYP2C19
SCHEMBL7055700 0.69 CPB1 (0.41) ALDH1A1GABRG2GABRB3GABRA5GABRA3
SCHEMBL6969995 0.69 ACP1 (0.45) NTRK1NTRK3NTRK2CYP1A2CYP2C19
SCHEMBL24427767 0.68 SCN8A (0.53) CYP1A2CYP2C19ALDH1A1HSD17B10CLK4
SCHEMBL7054048 0.68 GRIN2D (0.39) ALDH1A1MAPK1KDM4EMAPTLMNA
SCHEMBL7054047 0.68 GRIN2D (0.39) ALDH1A1MAPK1KDM4EMAPTLMNA
SCHEMBL6959349 0.67 VNN1 (0.47) NTRK1NTRK3NTRK2CYP1A2CYP2C19
SCHEMBL7050677 0.67 VNN1 (0.41) NTRK1NTRK3NTRK2CYP1A2CYP2C19
SCHEMBL8234870 0.67 HTT (0.57) CYP1A2CYP2C19ALDH1A1HSD17B10CLK4
SCHEMBL320058 0.66 LOXL2 (0.59) CYP3A4KDM4EMAPTVNN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1304325-A1 5-(M-CYANOBENZYLAMINO)PYRAZOLE DERIVATIVES Sankyo Company, Limited (JP) 2003-04-23 EP disclosed