SCHEMBL538834

SCHEMBL538834

Cc1cn([C@H]2C[C@H](O)[C@@H](CI)O2)c(=O)[nH]c1=O

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TK1 P04183 4/20 0.65
POLB P06746 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3437095 1.00 TK1 (0.65) TK1POLB
SCHEMBL538835 1.00 TK1 (0.65) TK1POLB
SCHEMBL3437098 1.00 TK1 (0.65) TK1POLB
SCHEMBL25521507 1.00 TK1 (0.65) TK1POLB
SCHEMBL655193 0.92 TK1 (0.67) TK1POLB
SCHEMBL19224119 0.89 TK1 (0.69) TK1POLB
SCHEMBL14063727 0.89 TK1 (0.69) TK1POLB
Doxribtimine SCHEMBL10382149 0.89 TK1 (0.73) TK1
SCHEMBL12352406 0.89 TK1 (0.69) TK1POLB
Doxribtimine SCHEMBL21078835 0.89 TK1 (0.73) TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060160125-A1 Compositions and methods for nonenzymatic ligation of oligonucleotides and detection of genetic polymorphisms UNIVERSITY OF ROCHESTER (US) 2006-07-20 US claimed
EP-2677039-B1 Detection of nucleic acid targets using chemically reactive oligonucleotide probes DXTERITY DIAGNOSTICS (US) 2022-08-17 EP disclosed
US-10829803-B2 Detection of nucleic acid targets using chemically reactive oligonucleotide probes DXTERITY DIAGNOSTICS INCORPORATED (US) 2020-11-10 US disclosed
US-20190106739-A1 CHEMICAL LIGATION DEPENDENT PROBE AMPLIFICATION (CLPA) DXTERITY DIAGNOSTICS INCORPORATED 2019-04-11 US disclosed
US-10066257-B2 Methods and compositions for detecting target nucleic acids DXTERITY DIAGNOSTICS INCORPORATED (US) 2018-09-04 US disclosed
WO-2018143893-A1 IDOXURIDINE AND ITS ANALOGS AS NEUROPROTECTANS FOR THE TREATMENT OF PARKINSONISM SVENNINGSSON PER (SE) 2018-08-09 WO disclosed
US-9976177-B2 Chemical ligation dependent probe amplification (CLPA) DXTERITY DIAGNOSTICS INCORPORATED (US) 2018-05-22 US disclosed
US-20180030520-A1 METHODS AND COMPOSITIONS FOR DETECTING TARGET NUCLEIC ACIDS DXTERITY DIAGNOSTICS INCORPORATED 2018-02-01 US disclosed
US-9745616-B2 Methods and compositions for detecting target nucleic acids DXTERITY DIAGNOSTICS INCORPORATED (US) 2017-08-29 US disclosed
US-9696303-B2 Assay device RevoluGen Limited (GB) 2017-07-04 US disclosed
EP-0767668-A4 POLYNUCLEOSIDE CHAIN HAVING MULTIPLE NUCLEOSIDES, THE NUCLEOSIDES COUPLED BY GUANIDYL LINKAGES UNIV CALIFORNIA (US) 1998-04-08 EP disclosed
US-5677439-A PREVENTION GENE EXPRESSION SANOFI (FR) 1997-10-14 US disclosed
WO-1997035869-A1 DINUCLEOTIDE AND OLIGONUCLEOTIDE ANALOGUES NOVARTIS AG (CH) 1997-10-02 WO disclosed
EP-0767668-A1 POLYNUCLEOSIDE CHAIN HAVING MULTIPLE NUCLEOSIDES, THE NUCLEOSIDES COUPLED BY GUANIDYL LINKAGES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-04-16 EP disclosed
WO-1996000575-A1 POLYNUCLEOSIDE CHAIN HAVING MULTIPLE NUCLEOSIDES, THE NUCLEOSIDES COUPLED BY GUANIDYL LINKAGES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-01-11 WO disclosed
EP-0541722-B1 COMPOUNDS AND METHODS FOR INHIBITING GENE EXPRESSION STERLING WINTHROP INC (US) 1995-12-20 EP disclosed
US-5449664-A Nucleosides SYNTEX (U.S.A.) INC. (US) 1995-09-12 US disclosed
EP-0541722-A1 COMPOUNDS AND METHODS FOR INHIBITING GENE EXPRESSION. STERLING WINTHROP INC (US) 1993-05-19 EP disclosed
WO-1992002534-A2 COMPOUNDS AND METHODS FOR INHIBITING GENE EXPRESSION STERLING DRUG, INC. (US) 1992-02-20 WO disclosed
EP-0371366-A1 Antiviral agents SYNTEX (U.S.A.) INC. (US) 1990-06-06 EP disclosed