SCHEMBL655193

SCHEMBL655193

Cc1cn([C@H]2C[C@H](O)[C@@H](C[O])O2)c(=O)[nH]c1=O

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TK1 P04183 4/20 0.67
POLB P06746 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3437098 0.92 TK1 (0.65) TK1POLB
SCHEMBL3437095 0.92 TK1 (0.65) TK1POLB
SCHEMBL25521507 0.92 TK1 (0.65) TK1POLB
SCHEMBL538835 0.92 TK1 (0.65) TK1POLB
SCHEMBL538834 0.92 TK1 (0.65) TK1POLB
Doxribtimine SCHEMBL12296879 0.91 TK1 (0.73) TK1
SCHEMBL12352406 0.91 TK1 (0.69) TK1POLB
Doxribtimine SCHEMBL10382149 0.91 TK1 (0.73) TK1
SCHEMBL14063727 0.91 TK1 (0.69) TK1POLB
SCHEMBL19224119 0.91 TK1 (0.69) TK1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 412 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240150508-A1 PHOTO-SWITCHABLE CHEMISTRY FOR REVERSIBLE HYDROGELS AND REUSABLE FLOW CELLS ILLUMINA, INC. (US) 2024-05-09 US claimed
WO-2024081563-A1 PHOTO-SWITCHABLE CHEMISTRY FOR REVERSIBLE HYDROGELS AND REUSABLE FLOW CELLS ILLUMINA, INC. (US) 2024-04-18 WO claimed
WO-2020251933-A1 COMPOSITIONS COMPRISING FULLERENYL MESOCHLORIN NANO-PHOTOSENSITIZERS WITH COVALENTLY BOUND ANTIBIOTICS AND THEIR USES IN COMBINATION THERAPY THE UNIVERSITY OF MASSACHUSETTS (US) 2020-12-17 WO claimed
CN-107074911-B Peptide nucleic acid monomers and oligomers 优基艾森斯股份公司 2020-11-03 CN claimed
US-20150080564-A1 SYNTHESIS AND USES OF NUCLEIC ACID COMPOUNDS WITH CONFORMATIONALLY RESTRICTED MONOMERS MARINA BIOTECH, INC. (US) 2015-03-19 US claimed
US-8557982-B2 Tubulin polymerisation inhibitors BIONOMICS LIMITED (AU) 2013-10-15 US claimed
WO-2013036868-A1 SYNTHESIS AND USES OF NUCLEIC ACID COMPOUNDS WITH CONFORMATIONALLY RESTRICTED MONOMERS MARINA BIOTECH INC. (US) 2013-03-14 WO claimed
US-20120309768-A1 NOVEL TUBULIN POLYMERISATION INHIBITORS BIONOMICS LIMITED (AU) 2012-12-06 US claimed
US-8278290-B2 Tubulin polymerisation inhibitors Biononics Limited (AU) 2012-10-02 US claimed
US-20100292190-A1 NOVEL TUBULIN POLYMERISATION INHIBITORS BIONOMICS LIMITED (AU) 2010-11-18 US claimed
US-6380434-B1 HYDROXYLATION; AMINATION SETHNANOTECHNOLOGY, INCORPORATED 2002-04-30 US claimed
US-6303774-B1 ANTIVIRAL AGENTS, ANTICANCER AGENTS, METABOLIC MODERATORS SRI INTERNATIONAL 2001-10-16 US claimed
EP-1132380-A1 E-Isomeric fullerene derivatives Chiang, Long Y. (TW) 2001-09-12 EP claimed
US-5760013-A TREATING HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 NATIONAL SCIENCE COUNCIL (TW) 1998-06-02 US claimed
EP-0653437-B1 Process for preparing AZT and derivatives thereof BRISTOL MYERS SQUIBB CO (US) 1997-08-13 EP claimed
US-5604294-A IMMUNOSUPRESSIVE, ANTIMICROBIAL, ANTIFUNGAL, ANTIVIRAL, ANTI-INFLAMMATORY AND ANTIPROLIFERATIVE ACTIVITY ABBOTT LABORATORIES 1997-02-18 US claimed
US-5565555-A Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues GILEAD SCIENCES, INC. (US) 1996-10-15 US claimed
US-5194599-A Forming linkages with nuclosides and nucleotides; viricides, anticarcinogenic agents GILEAD SCIENCES, INC. (US) 1993-03-16 US claimed
EP-0360609-A2 Novel hydrogen phosphonodithioate compositions GILEAD SCIENCES, INC. (US) 1990-03-28 EP claimed
US-4689321-A CYTOLYSIS, ANTITUMOR, ANTICARCINOGENIC THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 1987-08-25 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150080564-A1 SYNTHESIS AND USES OF NUCLEIC ACID COMPOUNDS WITH CONFORMATIONALLY RESTRICTED MONOMERS POLN, NSUN2, POLM TK1 617/4885POLB 91/4885
US-20100292190-A1 NOVEL TUBULIN POLYMERISATION INHIBITORS TUBB1, TUBA1C, TUBB TK1 312/4885POLB 680/4885
US-20120309768-A1 NOVEL TUBULIN POLYMERISATION INHIBITORS TUBB1, TUBA1C, TUBB TK1 312/4885POLB 680/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.