Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | TYR | P14679 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5388897 | 1.00 | APP (0.65) | APPPOLBTYRALDH1A1KDM4E | |
| SCHEMBL5388899 | 1.00 | APP (0.65) | APPPOLBTYRALDH1A1KDM4E | |
| SCHEMBL13926059 | 0.90 | APP (0.73) | APPALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8205579 | 0.87 | APP (0.65) | APPALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL23143178 | 0.85 | APP (0.68) | APPALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL30075229 | 0.85 | APP (0.68) | APPALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL23143168 | 0.85 | APP (0.68) | APPALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL2934800 | 0.83 | ALDH1A1 (0.61) | APPPOLBALDH1A1KDM4EHPGD | |
| SCHEMBL29956561 | 0.83 | ALDH1A1 (0.61) | APPPOLBALDH1A1KDM4EHPGD | |
| SCHEMBL10167884 | 0.83 | PTPN1 (0.73) | APPKDM4ESMN1; SMN2PTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113423735-B | Anti-claudin antibodies and uses thereof | 再鼎医药(上海)有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-114306183-A | Novel use of plant-derived alkaline phosphatase expression promoter | 香港科技大学 | 2022-04-12 | — | — | CN | disclosed |
| US-7253198-B2 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-08-07 | — | — | US | disclosed |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | BACE2, PSEN2, BACE1 | APP 5/4885POLB 723/4885TYR 1342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.