Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.65 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.56 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 3/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13926059 | 0.93 | APP (0.73) | APPPTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL23143178 | 0.89 | APP (0.68) | APPPTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL30075229 | 0.89 | APP (0.68) | APPPTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL23143168 | 0.89 | APP (0.68) | APPPTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL5388897 | 0.87 | APP (0.65) | APPPTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL5388899 | 0.87 | APP (0.65) | APPPTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL5388902 | 0.87 | APP (0.65) | APPPTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL10167884 | 0.86 | PTPN1 (0.73) | APPPTPN2PTPN1PTPN6KDM4E | |
| SCHEMBL2934800 | 0.83 | ALDH1A1 (0.61) | APPPTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL29956561 | 0.83 | ALDH1A1 (0.61) | APPPTPN2PTPN1PTPN6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977815-A1 | ALKYL, ALKENYL AND ALKYNYL CHRYSAMINE G DERIVATIVES FOR THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND $i(IN VIVO) IMAGING AND PREVENTION OF AMYLOID DEPOSITION | UNIVERSITY OF PITTSBURGH (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998047969-A1 | ALKYL, ALKENYL AND ALKYNYL CHRYSAMINE G DERIVATIVES FOR THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | UNIVERSITY OF PITTSBURGH (US) | 1998-10-29 | — | — | WO | disclosed |