Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5383096 | 0.86 | AR (0.46) | KDRGRM4 | |
| SCHEMBL5376240 | 0.79 | EPHX2 (0.50) | KMT2AMAPTEPHX2MEN1 | |
| SCHEMBL5911707 | 0.79 | KDR (0.58) | KDRKMT2APDK1MAPTEPHX2 | |
| SCHEMBL5911832 | 0.79 | KDR (0.58) | KDRKMT2APDK1MAPTEPHX2 | |
| SCHEMBL5374656 | 0.78 | SMN1; SMN2 (0.56) | KMT2AMAPTEPHX2SMN1; SMN2MEN1 | |
| SCHEMBL5911648 | 0.77 | KDR (0.56) | KDRKMT2APDK1MAPTEPHX2 | |
| SCHEMBL5371798 | 0.77 | MAPT (0.45) | KMT2AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL11493547 | 0.77 | KDR (0.58) | KDRKMT2APDK1MAPTEPHX2 | |
| SCHEMBL9835641 | 0.75 | KDR (0.78) | KDRKMT2APDK1MAPTNPSR1 | |
| SCHEMBL5911685 | 0.75 | KDR (0.53) | KDRKMT2APDK1MAPTEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179943-B2 | Bicyclic derivatives that modulate voltage-gated potassium channels and methods of use thereof | WYETH (US) | 2007-02-20 | — | — | US | claimed |
| US-20060004108-A1 | Bicyclic derivatives that modulate voltage-gated potassium channels and methods of use thereof | WYETH (US) | 2006-01-05 | — | — | US | claimed |
| US-7179943-B2 | Bicyclic derivatives that modulate voltage-gated potassium channels and methods of use thereof | WYETH (US) | 2007-02-20 | — | — | US | disclosed |
| US-20060004108-A1 | Bicyclic derivatives that modulate voltage-gated potassium channels and methods of use thereof | WYETH (US) | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004108-A1 | Bicyclic derivatives that modulate voltage-gated potassium channels and methods of use thereof | KCNAB1, KCNA1, KCNN1 | KDR 1571/4885KMT2A 1307/4885PDK1 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.