Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.78 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.69 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA7 | P43166 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.59 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.59 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29364392 | 0.88 | KDR (1.00) | KDRPDK1GRM4TRPV1CA1 | |
| SCHEMBL118026 | 0.88 | KDR (1.00) | KDRPDK1GRM4TRPV1CA1 | |
| SCHEMBL2329430 | 0.86 | KDR (0.78) | KDRPDK1GRM4TRPV1NPSR1 | |
| SCHEMBL10885507 | 0.86 | KDR (0.78) | KDRPDK1GRM4TRPV1NPSR1 | |
| SCHEMBL29759440 | 0.85 | KDR (0.76) | KDRPDK1GRM4TRPV1NPSR1 | |
| SCHEMBL26546756 | 0.85 | KDR (0.76) | KDRPDK1GRM4TRPV1NPSR1 | |
| SCHEMBL31495074 | 0.85 | KDR (0.76) | KDRPDK1GRM4TRPV1NPSR1 | |
| SCHEMBL2457115 | 0.85 | KDR (0.76) | KDRPDK1GRM4TRPV1NPSR1 | |
| Fluoride SCHEMBL11788392 | 0.85 | KDR (0.76) | KDRPDK1GRM4TRPV1NPSR1 | |
| SCHEMBL462753 | 0.85 | KDR (0.76) | KDRPDK1GRM4TRPV1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105399668-B | A kind of method that \" one kettle way \" prepares Sorafenib | 开封制药(集团)有限公司 | 2018-11-16 | — | — | CN | disclosed |
| CN-105399668-A | Method for preparing sorafenib through one-pot process | KAIFENG PHARMACEUTICAL (GROUP) CO LTD | 2016-03-16 | — | — | CN | disclosed |
| CN-105399668-A | Method for preparing sorafenib through one-pot process | KAIFENG PHARMACEUTICAL (GROUP) CO LTD | 2016-03-16 | — | — | CN | disclosed |
| CN-103724258-B | Preparation method of sorafenib | QILU PHARMACEUTICAL CO LTD | 2015-05-13 | — | — | CN | disclosed |
| CN-103724258-A | Preparation method of sorafenib | QILU PHARMACEUTICAL CO LTD | 2014-04-16 | — | — | CN | disclosed |
| EP-0241559-B1 | OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-10-30 | — | — | EP | disclosed |
| US-4983751-A | Chemical intermediates | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-01-08 | — | — | US | disclosed |
| US-4818272-A | NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1989-04-04 | — | — | US | disclosed |
| EP-0241559-A1 | OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1987-10-21 | — | — | EP | disclosed |