Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.75 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.75 |
| ▸ | RAB9A | P51151 | 3/20 | 0.72 |
| ▸ | TP53 | P04637 | 2/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | KCNK3 | O14649 | 7/20 | 0.69 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 7/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | NT5E | P21589 | 1/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257440 | 0.87 | NPC1 (0.81) | HDAC8HDAC6RAB9ATP53NPC1 | |
| SCHEMBL30048093 | 0.87 | NPC1 (0.81) | HDAC8HDAC6RAB9ATP53NPC1 | |
| SCHEMBL5242529 | 0.87 | HDAC6 (1.00) | HDAC8HDAC6RAB9ATP53NPC1 | |
| SCHEMBL30929655 | 0.87 | HDAC6 (1.00) | HDAC8HDAC6RAB9ATP53NPC1 | |
| SCHEMBL7822889 | 0.86 | MEN1 (0.78) | RAB9ATP53NPC1KCNK3KCNK9 | |
| SCHEMBL12259119 | 0.86 | TP53 (0.78) | HDAC8HDAC6RAB9ATP53NPC1 | |
| SCHEMBL12259175 | 0.85 | POLB (0.76) | RAB9ATP53NPC1KCNK3KCNK9 | |
| SCHEMBL14490979 | 0.84 | PARP1 (0.71) | HDAC8HDAC6RAB9ANPC1KCNK3 | |
| SCHEMBL25863680 | 0.84 | KMT2A (0.77) | RAB9ATP53NPC1KCNK3KCNK9 | |
| SCHEMBL5380687 | 0.84 | TP53 (1.00) | RAB9ATP53NPC1KCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282522-B2 | Hydroxamic acid derivatives and the method for preparing thereof | AMOREPACIFIC CORPORATION (KR) | 2007-10-16 | — | — | US | claimed |
| US-20170020874-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | CERENO SCIENT AB (SE) | 2017-01-26 | — | — | US | disclosed |
| US-20140051716-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | CERENO SCIENTIFIC AB | 2014-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051716-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC2 | HDAC8 4/4885HDAC6 10/4885RAB9A 3597/4885 |
| US-20170020874-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC2 | HDAC8 4/4885HDAC6 10/4885RAB9A 3597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.