Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.65 |
| ▸ | TP53 | P04637 | 5/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | MMP2 | P08253 | 1/20 | 0.62 |
| ▸ | MMP9 | P14780 | 1/20 | 0.62 |
| ▸ | MMP8 | P22894 | 1/20 | 0.62 |
| ▸ | MMP13 | P45452 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12316854 | 0.87 | MAPT (0.77) | MAPTHSD17B10TP53HPGDGAA | |
| SCHEMBL24710856 | 0.80 | THRB (0.70) | MAPTHSD17B10TP53HPGDTHRB | |
| SCHEMBL16217094 | 0.78 | MAPT (0.92) | MAPTTP53THRBPOLBPTGS2 | |
| SCHEMBL2244186 | 0.78 | MAPT (0.92) | MAPTTP53THRBPOLBPTGS2 | |
| SCHEMBL16217101 | 0.78 | PTGS2 (0.78) | MAPTHSD17B10TP53HPGDGAA | |
| SCHEMBL2245332 | 0.78 | MAPT (0.87) | MAPTHSD17B10TP53HPGDGAA | |
| SCHEMBL2245479 | 0.78 | MAPT (0.87) | MAPTHSD17B10TP53HPGDGAA | |
| SCHEMBL2241942 | 0.78 | NPC1 (0.75) | MAPTHSD17B10TP53HPGDGAA | |
| SCHEMBL13464714 | 0.78 | MAPT (1.00) | MAPTHSD17B10TP53HPGDGAA | |
| SCHEMBL24710832 | 0.77 | TP53 (0.66) | MAPTHSD17B10TP53HPGDTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285410-B2 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-10-23 | — | — | US | disclosed |
| US-7220562-B2 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-05-22 | — | — | US | disclosed |
| US-7198926-B2 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-04-03 | — | — | US | disclosed |
| US-20070037264-A1 | Using trangenic microorganism having nitrilase and amidase activities to convert (E,Z)-2-methyl-2-butenenitrile into (E and Z)-2-methyl-2-butenoic acids | BRAMUCCI MICHAEL G | 2007-02-15 | — | — | US | disclosed |
| US-20060115883-A1 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids | BRAMUCCI MICHAEL G | 2006-06-01 | — | — | US | disclosed |
| WO-2004101513-A2 | PREPARATION OF (E)- AND (Z)-2-METHYL-2-BUTENOIC ACIDS | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2004-11-25 | — | — | WO | disclosed |
| US-20040224395-A1 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids | E. I. DU PONT DE NEMOURS AND COMPANY | 2004-11-11 | — | — | US | disclosed |