Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | FNTA | P49354 | 2/20 | 0.37 |
| ▸ | FNTB | P49356 | 2/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11474179 | 0.89 | TSHR (0.46) | TSHRNPSR1PTGS1MEN1KMT2A | |
| SCHEMBL3880467 | 0.87 | TSHR (0.60) | TSHRPTGS1MEN1KMT2ACYP2D6 | |
| SCHEMBL30045078 | 0.87 | TSHR (0.60) | TSHRPTGS1MEN1KMT2ACYP2D6 | |
| SCHEMBL29890128 | 0.87 | TSHR (0.60) | TSHRPTGS1MEN1KMT2ACYP2D6 | |
| SCHEMBL192456 | 0.87 | TSHR (0.60) | TSHRPTGS1MEN1KMT2ACYP2D6 | |
| SCHEMBL1677135 | 0.87 | TSHR (0.60) | TSHRPTGS1MEN1KMT2ACYP2D6 | |
| SCHEMBL11233625 | 0.85 | TSHR (0.44) | TSHRPTGS1MEN1KMT2ACYP2D6 | |
| SCHEMBL359346 | 0.85 | TSHR (0.44) | TSHRPTGS1MEN1KMT2ACYP2D6 | |
| SCHEMBL10507535 | 0.85 | TSHR (0.44) | TSHRNPSR1PTGS1MEN1KMT2A | |
| SCHEMBL11248942 | 0.85 | TSHR (0.44) | TSHRNPSR1PTGS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012150206-A2 | NOVEL CYCLOPROPANOIC ACID ESTER DERIVATIVES AS PEST CONTROL AGENTS | BAYER CROPSCIENCE AG (DE) | 2012-11-08 | — | — | WO | disclosed |
| WO-2012150207-A1 | USE OF CYCLOPROPANECARBOXYLIC ACID ESTER DERIVATIVES FOR CONTROLLING INSECTICIDE-RESISTANT INSECTS | BAYER CROPSCIENCE AG (DE) | 2012-11-08 | — | — | WO | disclosed |
| US-7223758-B2 | Pyridazine derivative, pharmaceutical composition thereof, its pharmaceutical use, and process for its preparation | SANOFI-AVENTIS (FR) | 2007-05-29 | — | — | US | disclosed |
| EP-1476434-B1 | PYRIDAZINE DERIVATIVES, USE OF THE SAME AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR PRODUCING THE SAME | AVENTIS PHARMA SA (FR) | 2006-06-14 | — | — | EP | disclosed |
| US-20050165017-A1 | Pyridazine derivative, pharmaceutical composition thereof, its pharmaceutical use, and process for its preparation | AVENTIS PHARMA S.A. (FR) | 2005-07-28 | — | — | US | disclosed |
| EP-1476434-A2 | PYRIDAZINE DERIVATIVES, USE OF THE SAME AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR PRODUCING THE SAME | Aventis Pharma S.A. (FR) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068140-A2 | NOVEL PYRIDAZINE DERIVATIVES, USE OF THE SAME AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR PRODUCING THE SAME | AVENTIS PHARMA S.A. (FR) | 2003-08-21 | — | — | WO | disclosed |
| US-4833163-A | INSECTICIDES, NEMATOCIDES, MITICIDES | ROUSSEL UCLAF (FR) | 1989-05-23 | — | — | US | disclosed |
| US-4303672-A | Cyclopropanecarboxylate insecticides and/or acaricides exhibiting low toxicity to mammals and fish | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-12-01 | — | — | US | disclosed |
| US-4265906-A | BROMOPHENOXYCYANOBENZYL CYCLOPROPANECARBOXYLATE DERIVATIVES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-05-05 | — | — | US | disclosed |
| US-4242357-A | INSECTICIDES, MITICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1980-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165017-A1 | Pyridazine derivative, pharmaceutical composition thereof, its pharmaceutical use, and process for its preparation | CYP3A5, IL5, CYP2C19 | TSHR 2605/4885NPSR1 1466/4885PTGS1 633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.