SCHEMBL539631

SCHEMBL539631

CC[C@@H](c1ccccc1)N1Cc2cc3c(cc2C[C@H]1C(=O)NC(Cc1ccc(-c2ccnc(C)c2C)cc1)C(=O)O)OC[C@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)O3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GLP1R P43220 19/20 1.00
AMY1A P0DUB6 1/20 0.90

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2019167 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL31709974 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL21551907 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL30069234 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL2019171 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL30746800 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL539630 1.00 GLP1R (1.00) GLP1RAMY1A
Hydrochloric Acid SCHEMBL21552133 0.99 GLP1R (1.00) GLP1RAMY1A
Hydrochloric Acid SCHEMBL21552139 0.99 GLP1R (1.00) GLP1RAMY1A
Hydrochloric Acid SCHEMBL21552137 0.99 GLP1R (1.00) GLP1RAMY1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3790549-A1 THERAPEUTIC USES OF GLP1R AGONISTS vTv Therapeutics LLC (US) 2021-03-17 EP claimed
US-20210023072-A1 THERAPEUTIC USES OF GLP1R AGONISTS VTV THERAPEUTICS LLC 2021-01-28 US claimed
WO-2019217165-A1 THERAPEUTIC USES OF GLP1R AGONISTS VTV THERAPEUTICS LLC (US) 2019-11-14 WO claimed
EP-2945618-B1 COMBINATIONS OF A GLP1R AGONIST AND METFORMIN AND USE THEREOF FOR THE TREATMENT OF TYPE 2 DIABETES AND OTHER DISORDERS VTV THERAPEUTICS LLC (US) 2018-06-13 EP claimed
EP-2413693-B1 SUBSTITUTED AZOANTHRACENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF VTV THERAPEUTICS LLC (US) 2015-09-09 EP claimed
US-8987295-B2 Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof TRANSTECH PHARMA, LLC (US) 2015-03-24 US claimed
US-20130096150-A1 Substituted Azoanthracene Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof TRANSTECH PHARMA, INC. (US) 2013-04-18 US claimed
US-8383644-B2 Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof TRANSTECH PHARMA, INC. (US) 2013-02-26 US claimed
US-20250325536-A1 THERAPEUTIC USES OF GLP1R AGONISTS VTV THERAPEUTICS LLC (US) 2025-10-23 US disclosed
EP-3790549-A1 THERAPEUTIC USES OF GLP1R AGONISTS vTv Therapeutics LLC (US) 2021-03-17 EP disclosed
US-20210023072-A1 THERAPEUTIC USES OF GLP1R AGONISTS VTV THERAPEUTICS LLC 2021-01-28 US disclosed
WO-2019217165-A1 THERAPEUTIC USES OF GLP1R AGONISTS VTV THERAPEUTICS LLC (US) 2019-11-14 WO disclosed
EP-2945618-B1 COMBINATIONS OF A GLP1R AGONIST AND METFORMIN AND USE THEREOF FOR THE TREATMENT OF TYPE 2 DIABETES AND OTHER DISORDERS VTV THERAPEUTICS LLC (US) 2018-06-13 EP disclosed
US-20150313908-A1 Combinations of a GLP1R Agonist and Metformin and Use Thereof for the Treatment of Type 2 Diabetes and Other Disorders VTV THERAPEUTICS LLC 2015-11-05 US disclosed
US-8987295-B2 Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof TRANSTECH PHARMA, LLC (US) 2015-03-24 US disclosed
US-20130096150-A1 Substituted Azoanthracene Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof TRANSTECH PHARMA, INC. (US) 2013-04-18 US disclosed
US-8383644-B2 Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof TRANSTECH PHARMA, INC. (US) 2013-02-26 US disclosed
EP-2413693-A1 SUBSTITUTED AZOANTHRACENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF TransTech Pharma, Inc (US) 2012-02-08 EP disclosed
US-20110160198-A1 SUBSTITUTED AZOANTHRACENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF HIGH POINT PHARMACEUTICALS, LLC (US) 2011-06-30 US disclosed
WO-2010114824-A1 SUBSTITUTED AZOANTHRACENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF TRANSTECH PHARMA INC (US) 2010-10-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130096150-A1 Substituted Azoanthracene Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof GLP1R, GIPR, GPR119 GLP1R 1/4885AMY1A 296/4885
US-20110160198-A1 SUBSTITUTED AZOANTHRACENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF GLP1R, GIPR, GPR119 GLP1R 1/4885AMY1A 296/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.