Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | FCER2 | P06734 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | YES1 | P07947 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7133388 | 0.84 | GSK3B (0.60) | SRCCDK2KDRGSK3BRET | |
| SCHEMBL5728093 | 0.80 | TLK2 (0.61) | SRCCDK2KDRPDGFRBJAK3 | |
| SCHEMBL5728094 | 0.80 | TLK2 (0.61) | SRCCDK2KDRPDGFRBJAK3 | |
| SCHEMBL5363782 | 0.80 | NOX4 (0.57) | SRCCDK2KDRPDGFRBJAK3 | |
| SCHEMBL5728095 | 0.79 | PDPK1 (0.73) | SRCCDK2KDRPDGFRBJAK3 | |
| SCHEMBL5363321 | 0.79 | PDPK1 (0.73) | SRCCDK2KDRPDGFRBJAK3 | |
| SCHEMBL5405110 | 0.79 | CDK2 (0.57) | SRCCDK2KDRPDGFRBNTRK1 | |
| SCHEMBL5728098 | 0.79 | MAPT (0.64) | SRCKDRPDGFRBJAK3NTRK1 | |
| SCHEMBL5728101 | 0.79 | MAPT (0.64) | SRCKDRPDGFRBJAK3NTRK1 | |
| SCHEMBL5368250 | 0.78 | SRC (0.55) | SRCCDK2KDRPDGFRBNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157577-B2 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-7157577-B2 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-20040266843-A1 | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) | SUGEN, INC. | 2004-12-30 | — | — | US | disclosed |
| US-20040204407-A1 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204407-A1 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | DMPK, MAP3K20, PHKG1 | SRC 297/4885CDK2 95/4885KDR 1657/4885 |
| US-20040266843-A1 | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) | CHEK2, CHEK1, ATM | SRC 663/4885CDK2 172/4885KDR 1541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.