Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 8/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.45 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.45 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5386494 | 0.90 | DRD2 (0.50) | HDAC3HDAC1HDAC8HDAC6DRD2 | |
| SCHEMBL5387082 | 0.89 | DRD2 (0.51) | HDAC3HDAC1HDAC8HDAC6DRD2 | |
| SCHEMBL5391426 | 0.86 | DRD2 (0.49) | HDAC3HDAC1HDAC8HDAC6DRD2 | |
| SCHEMBL8139824 | 0.86 | BRD4 (0.53) | HDAC3HDAC1HDAC8HDAC6DRD2 | |
| SCHEMBL31655700 | 0.85 | TPSAB1 (0.54) | HDAC3HDAC1HDAC8HDAC6DRD2 | |
| SCHEMBL22291518 | 0.85 | TPSAB1 (0.54) | HDAC3HDAC1HDAC8HDAC6DRD2 | |
| SCHEMBL9773851 | 0.85 | TPSAB1 (0.54) | HDAC3HDAC1HDAC8HDAC6DRD2 | |
| SCHEMBL5386708 | 0.84 | DRD2 (0.50) | HDAC3HDAC1HDAC8HDAC6DRD2 | |
| SCHEMBL18942729 | 0.83 | AKT1 (0.49) | HDAC3HDAC1HDAC8HDAC6DRD2 | |
| SCHEMBL25974776 | 0.82 | MALT1 (0.52) | HDAC3HDAC1HDAC8HDAC6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7192967-B1 | Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents | ASTELLAS PHARMA GMBH (DE) | 2007-03-20 | — | — | US | disclosed |
| EP-1042315-B1 | CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE CO CHEM PHARM FAB (DE) | 2004-04-14 | — | — | EP | disclosed |