SCHEMBL5396705

SCHEMBL5396705

CC1=C(C(=O)O)C(c2cccc([N+](=O)[O-])c2)C(C(=O)O)=C(C)N1CCC(c1ccccc1)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 5/20 0.48
CYP3A4 P08684 5/20 0.48
CYP2C9 P11712 5/20 0.48
CYP2C19 P33261 5/20 0.48
MAPT P10636 3/20 0.48
CYP2D6 P10635 3/20 0.48
TSHR P16473 3/20 0.48
NFKB1 P19838 3/20 0.48
LMNA P02545 3/20 0.48
GMNN O75496 1/20 0.48
BLM P54132 1/20 0.48
PMP22 Q01453 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
ADORA3 P0DMS8 3/20 0.48
MLNR O43193 2/20 0.48
NR1I2 O75469 2/20 0.48
ADRA1A P35348 2/20 0.48
SLC6A3 Q01959 2/20 0.48
CNR1 P21554 1/20 0.48
HRH1 P35367 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5396699 1.00 CYP1A2 (0.48) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL3443986 0.85 CYP1A2 (0.55) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL5415270 0.83 CACNA1B (0.44) LMNACCR5CACNA1BPYGLPYGM
SCHEMBL22658644 0.83 ADORA3 (0.53) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL30873727 0.83 CYP1A2 (0.57) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL20801670 0.83 CYP1A2 (0.55) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL7661495 0.83 ADRA1A (0.48) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL7661489 0.83 ADRA1A (0.48) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL5417914 0.82 CACNA1B (0.59) CCR5CACNA1BPYGLPYGM
SCHEMBL8403732 0.82 MAPT (0.50) CYP1A2CYP3A4CYP2C9CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7247645-B2 Dihydropyridine derivatives AJINOMOTO CO., INC. (JP) 2007-07-24 US disclosed