Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 11/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 5/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.42 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11720898 | 0.72 | NPC1 (0.36) | ALDH1A1SCN9A | |
| SCHEMBL5317949 | 0.68 | PARP10 (0.51) | PARP10PARP15PARP2ALDH1A1 | |
| SCHEMBL11717424 | 0.68 | NPC1 (0.36) | ALDH1A1 | |
| SCHEMBL11716274 | 0.68 | SLC6A3 (0.35) | ALDH1A1SCN9A | |
| SCHEMBL26693436 | 0.66 | PARP1 (0.51) | PARP10PARP15PARP2PARP1CYP2C9 | |
| SCHEMBL4767634 | 0.65 | PARP1 (0.50) | PARP10PARP15PARP2PARP1CYP2C9 | |
| SCHEMBL7769325 | 0.64 | PARP10 (0.61) | PARP10PARP15PARP2PARP4CA1 | |
| SCHEMBL16457757 | 0.64 | PARP10 (0.51) | PARP10PARP15PARP2PARP4CA1 | |
| SCHEMBL3028371 | 0.63 | PARP10 (0.93) | PARP10PARP15PARP2PARP4CA1 | |
| Piperidine SCHEMBL28849723 | 0.63 | PARP10 (0.70) | PARP10PARP15PARP2PARP4CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007092879-A2 | SUBSTITUTED THIATRIAZAACENAPHTHYLENE-6-CARBONITRILE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-08-16 | — | — | WO | claimed |