SCHEMBL4767634

SCHEMBL4767634

NC(=O)c1ccc(C2CCCCCCN2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 13/20 0.50
PARP2 Q9UGN5 4/20 0.50
PARP3 Q9Y6F1 1/20 0.44
PARP15 Q460N3 2/20 0.44
PARP10 Q53GL7 2/20 0.44
MEN1 O00255 2/20 0.44
CYP2D6 P10635 2/20 0.44
CYP2C19 P33261 2/20 0.44
KMT2A Q03164 2/20 0.44
POLB P06746 1/20 0.44
CHRNB2 P17787 1/20 0.44
CHRNA7 P36544 1/20 0.44
CHRNA4 P43681 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2A6 P11509 1/20 0.44
CYP2C9 P11712 1/20 0.44
MAP4K4 O95819 1/20 0.42
CSF1R P07333 1/20 0.42
PIM1 P11309 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26693436 0.98 PARP1 (0.51) PARP1PARP2PARP3PARP15PARP10
SCHEMBL3333833 0.93 PARP1 (0.50) PARP1PARP2PARP3PARP10CHRNB2
Trifluoroacetic Acid SCHEMBL26693369 0.84 PARP1 (0.44) PARP1PARP2PARP3CHRNB2CHRNA7
SCHEMBL16401323 0.83 KMT2A (0.46) PARP1PARP2MEN1CYP2D6CYP2C19
SCHEMBL4045246 0.83 KMT2A (0.46) PARP1PARP2MEN1CYP2D6CYP2C19
SCHEMBL4045684 0.82 MEN1 (0.45) PARP1PARP2MEN1CYP2D6CYP2C19
SCHEMBL17782257 0.78 ALDH1A1 (0.47) MEN1CYP2D6CYP2C19KMT2APOLB
SCHEMBL3529098 0.78 ALDH1A1 (0.47) MEN1CYP2D6CYP2C19KMT2APOLB
SCHEMBL28580499 0.78 PRKAB2 (0.48) PARP1PARP2PARP3MEN1CYP2D6
SCHEMBL17074055 0.78 MEN1 (0.50) PARP1PARP2MEN1CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940835-A1 PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS GLAXO GROUP LIMITED (GB) 2008-07-09 EP disclosed
WO-2007036733-A1 PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS GLAXO GROUP LIMITED (GB) 2007-04-05 WO disclosed