Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.34 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057102 | 0.86 | MEN1 (0.44) | MEN1KMT2AIRAK4FNTAFNTB | |
| SCHEMBL4054077 | 0.79 | ABCG2 (0.40) | PDE4BADORA1ABCB1ABCC1ABCG2 | |
| SCHEMBL4049335 | 0.76 | TBXAS1 (0.46) | PDE4BADORA1ABL1PDGFRBBCR | |
| SCHEMBL4050378 | 0.76 | TBXAS1 (0.46) | HDAC1PDE4BADORA1 | |
| SCHEMBL4053260 | 0.75 | MEN1 (0.55) | MEN1KMT2APDE4BABCC1ABCG2 | |
| SCHEMBL4053319 | 0.74 | CYP11B2 (0.46) | ABL1PDGFRBBCRPDGFRAPRKCA | |
| SCHEMBL4061317 | 0.73 | ABCG2 (0.54) | PDE4BADORA1ABCB1ABCC1ABCG2 | |
| SCHEMBL4053653 | 0.73 | PDE4B (0.44) | MEN1KMT2APDE4BADORA1CYP1A2 | |
| SCHEMBL5751896 | 0.72 | MAPT (0.46) | MEN1KMT2APDE4BKDM4ECYP1A2 | |
| SCHEMBL4062409 | 0.70 | PDE4B (0.40) | PDE4BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007510689-A | — | — | 2007-04-26 | — | — | JP | claimed |
| EP-1682519-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2006-07-26 | — | — | EP | claimed |
| WO-2005049581-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA, S.A. (ES) | 2005-06-02 | — | — | WO | claimed |