Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5354933 | 0.91 | L3MBTL1 (0.47) | MAPTLMNASMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL5252743 | 0.78 | PDE5A (0.42) | MAPTLMNASMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL5221451 | 0.77 | XIAP (0.39) | MAPTLMNASMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL5215989 | 0.77 | MAPT (0.63) | MAPTLMNASMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL5252659 | 0.76 | ALDH1A1 (0.49) | MAPTSMN1; SMN2L3MBTL1RAB9ANPC1 | |
| SCHEMBL5216421 | 0.76 | LPAR1 (0.52) | MAPTLMNASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL5220598 | 0.74 | HSD17B10 (0.50) | MAPTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5217930 | 0.74 | KCNJ6 (0.48) | MAPTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5221118 | 0.73 | LPAR1 (0.51) | L3MBTL1KMT2AMEN1POLB | |
| SCHEMBL5219334 | 0.73 | MEN1 (0.48) | MAPTLMNASMN1; SMN2TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809380-A2 | INHIBITORS OF HIV-1 CAPSID FORMATION: SUBSTITUTED ARYL AMINOMETHYL THIAZOLE UREAS AND ANALOGUES THEREOF | Achillion Pharmaceuticals, Inc. (US) | 2007-07-25 | — | — | EP | claimed |
| WO-2006053323-A2 | INHIBITORS OF HIV-1 CAPSID FORMATION: SUBSTITUTED ARYL AMINOMETHYL THIAZOLE UREAS AND ANALOGUES THEREOF | ACHILLION PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |