Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | ATP4A | P20648 | 1/20 | 0.40 |
| ▸ | ATP4B | P51164 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5403596 | 0.84 | CYP19A1 (0.45) | CYP19A1DRD2DRD4DRD3ATP4A | |
| SCHEMBL5403605 | 0.81 | KDM4E (0.56) | CYP19A1ATP4AATP4BRAB9ANPC1 | |
| SCHEMBL3115301 | 0.76 | RAB9A (0.56) | CYP19A1RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL6419690 | 0.76 | CYP11B1 (0.43) | CYP19A1DRD2DRD4DRD3ATP4A | |
| SCHEMBL27605964 | 0.74 | CYP19A1 (0.67) | CYP19A1 | |
| SCHEMBL5389932 | 0.73 | DRD2 (0.39) | CYP19A1DRD2DRD4DRD3KLK1 | |
| SCHEMBL533107 | 0.71 | RAB9A (0.53) | DRD2DRD4DRD3GFERRAB9A | |
| SCHEMBL2105505 | 0.71 | GFER (0.45) | DRD2DRD4DRD3GFERRAB9A | |
| SCHEMBL446528 | 0.71 | SMN1; SMN2 (0.57) | DRD2DRD4DRD3RAB9ANPC1 | |
| SCHEMBL533222 | 0.71 | GFER (0.41) | DRD2DRD4DRD3GFERRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259262-B2 | Arylazole derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-20050124670-A1 | Novel arylazole derivatives, their manufacture and use as pharmaceutical agents | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124670-A1 | Novel arylazole derivatives, their manufacture and use as pharmaceutical agents | CYP3A43, CYP3A5, CYP1A1 | CYP19A1 96/4885DRD2 2009/4885DRD4 2243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.