Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL5478391 | 0.92 | THRB (0.57) | TSHRTHRBTDP1ALDH1A1POLB | |
| SCHEMBL4450451 | 0.89 | TSHR (0.58) | TSHRTHRBTDP1ALDH1A1POLB | |
| SCHEMBL6864388 | 0.88 | THRB (0.59) | TSHRTHRBTDP1ALDH1A1POLB | |
| SCHEMBL29229747 | 0.88 | THRB (0.59) | TSHRTHRBTDP1ALDH1A1POLB | |
| SCHEMBL14886 | 0.88 | — | — | |
| Propylene Glycol SCHEMBL8850620 | 0.87 | THRB (0.61) | TSHRTHRBTDP1ALDH1A1POLB | |
| Propylene Glycol SCHEMBL8850396 | 0.87 | THRB (0.61) | TSHRTHRBTDP1ALDH1A1POLB | |
| Lactic Acid SCHEMBL3883208 | 0.87 | TSHR (0.50) | TSHRTHRBTDP1ALDH1A1POLB | |
| Ethylene SCHEMBL10530398 | 0.86 | THRB (0.57) | TSHRTHRBTDP1ALDH1A1POLB | |
| SCHEMBL8743335 | 0.86 | THRB (0.57) | TSHRTHRBTDP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662340-B2 | Liquid concentrate of solid particles of hybrid pigments containing grafted copolymers and use of same for preparing paints in an aqueous and/or organic medium | COLORIS GLOBAL COLORING CONCEPT (FR) | 2020-05-26 | — | — | US | claimed |
| EP-3387075-B1 | LIQUID CONCENTRATE OF SOLID PARTICLES OF HYBRID PIGMENTS CONTAINING GRAFTED COPOLYMERS AND USE OF SAME FOR PREPARING PAINTS IN AN AQUEOUS AND/OR ORGANIC MEDIUM | COLORIS GLOBAL COLORING CONCEPT (FR) | 2020-03-04 | — | — | EP | claimed |
| US-20180355192-A1 | LIQUID CONCENTRATE OF SOLID PARTICLES OF HYBRID PIGMENTS CONTAINING GRAFTED COPOLYMERS AND USE OF SAME FOR PREPARING PAINTS IN AN AQUEOUS AND/OR ORGANIC MEDIUM | COLORIS GLOBAL COLORING CONCEPT (FR) | 2018-12-13 | — | — | US | claimed |
| WO-2024106158-A1 | RANDOM COPOLYMER, COATING COMPOSITION AND RESIST COMPOSITION CONTAINING SAID COPOLYMER | DIC株式会社 | 2024-05-23 | — | — | WO | disclosed |
| WO-2024101164-A1 | RESIST COMPOSITION AND CURED PRODUCT OF SAME | DIC株式会社 | 2024-05-16 | — | — | WO | disclosed |
| WO-2024084977-A1 | ANTIFOAMING AGENT, LUBRICATING OIL COMPOSITION CONTAINING SAID ANTIFOAMING AGENT, AND MACHINE EMPLOYING SAID LUBRICATING OIL COMPOSITION | DIC株式会社 | 2024-04-25 | — | — | WO | disclosed |
| EP-3572473-B1 | AQUEOUS COATING COMPOSITION AND METHOD FOR FORMING MULTILAYERED COATING FILM | KANSAI PAINT CO LTD (JP) | 2022-07-06 | — | — | EP | disclosed |
| CN-108368352-B | Liquid concentrates of solid particles of mixed pigments containing graft copolymers and their use for preparing paints in aqueous and/or organic medium | 色彩全球着色概念公司 | 2021-04-02 | — | — | CN | disclosed |
| US-10662340-B2 | Liquid concentrate of solid particles of hybrid pigments containing grafted copolymers and use of same for preparing paints in an aqueous and/or organic medium | COLORIS GLOBAL COLORING CONCEPT (FR) | 2020-05-26 | — | — | US | disclosed |
| US-20200048492-A1 | AQUEOUS COATING COMPOSITION AND METHOD FOR FORMING MULTILAYERED COATING FILM | KANSAI PAINT CO., LTD. (JP) | 2020-02-13 | — | — | US | disclosed |
| US-10370472-B2 | Ethylene copolymerisates having improved low-temperature properties and good oil resistance, vulcanizable mixtures made therefrom and vulcanizates | ARLANXEO DEUTSCHLAND GMBH (DE) | 2019-08-06 | — | — | US | disclosed |
| US-20070209550-A1 | WATER-BASED INK | KAO CORPORATION (JP) | 2007-09-13 | — | — | US | disclosed |
| EP-1704245-A1 | MULTIPLEX PROTEASE PROFILING | Applera Corporation (US) | 2006-09-27 | — | — | EP | disclosed |
| US-20050176076-A1 | Multiplex protease profiling | APPLERA CORPORATION | 2005-08-11 | — | — | US | disclosed |
| WO-2005066359-A1 | MULTIPLEX PROTEASE PROFILING | APPLERA CORPORATION (US) | 2005-07-21 | — | — | WO | disclosed |
| US-20050027036-A1 | Aqueous ink for ink jet printer recording | KAO CORPORATION (JP) | 2005-02-03 | — | — | US | disclosed |
| EP-1493785-A1 | Aqueous ink for ink jet printer recording | KAO CORPORATION (JP) | 2005-01-05 | — | — | EP | disclosed |
| US-20040030002-A1 | Water-based ink | KAO CORPORATION (JP) | 2004-02-12 | — | — | US | disclosed |
| US-20030144378-A1 | Water-based ink | KAO CORPORATION (JP) | 2003-07-31 | — | — | US | disclosed |
| EP-1323789-A1 | Water-based ink | Kao Corporation (JP) | 2003-07-02 | — | — | EP | disclosed |