Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | RAD51 | Q06609 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.49 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20379647 | 0.91 | ALDH1A1 (0.64) | ALDH1A1MAPTRAD51KMT2AMEN1 | |
| Phenyl 4-Chlorophenylcarbamate SCHEMBL6258165 | 0.89 | ALDH1A1 (0.70) | ALDH1A1MAPTRAD51KMT2AMEN1 | |
| SCHEMBL24974648 | 0.88 | ALDH1A1 (0.60) | ALDH1A1MAPTRAD51KMT2AMEN1 | |
| SCHEMBL20379375 | 0.88 | ABCC9 (0.55) | ALDH1A1MAPTRAD51KMT2AMEN1 | |
| SCHEMBL20379632 | 0.87 | RAD51 (0.55) | ALDH1A1MAPTRAD51KMT2AMEN1 | |
| SCHEMBL23431994 | 0.86 | NAMPT (0.52) | ALDH1A1MAPTRAD51KMT2AMEN1 | |
| SCHEMBL20379864 | 0.85 | NAMPT (0.53) | ALDH1A1MAPTRAD51KMT2AMEN1 | |
| SCHEMBL20379374 | 0.84 | ALDH1A1 (0.73) | ALDH1A1MAPTRAD51KMT2AMEN1 | |
| SCHEMBL20381423 | 0.84 | RAD51 (0.55) | ALDH1A1MAPTRAD51KMT2AMEN1 | |
| SCHEMBL5406539 | 0.84 | SMN1; SMN2 (0.64) | ALDH1A1MAPTRAD51KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202269-B2 | GlyT2 modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-10 | — | — | US | disclosed |
| US-20050119245-A1 | GlyT2 modulators | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-06-02 | — | — | US | disclosed |
| WO-2005044810-A1 | GLYT2 MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119245-A1 | GlyT2 modulators | GLRB, GLRA1, GLRA2 | ALDH1A1 3023/4885MAPT 450/4885RAD51 4489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.