Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 5/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.42 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 5/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5391006 | 0.95 | TOP2A (0.44) | TOP2ATOP2BRBP4GAAKMT2A | |
| SCHEMBL5393960 | 0.94 | TOP2A (0.43) | TOP2ATOP2BGAAKMT2AHTR1A | |
| SCHEMBL5398763 | 0.93 | TOP2A (0.42) | TOP2ATOP2BKMT2AHTR1AHTR1D | |
| SCHEMBL5401644 | 0.93 | TOP2A (0.42) | TOP2ATOP2BKMT2AHTR1AHTR1D | |
| SCHEMBL5395198 | 0.92 | TOP2A (0.41) | TOP2ATOP2BRBP4HTR1AHTR1D | |
| SCHEMBL5401099 | 0.91 | TOP2A (0.42) | TOP2ATOP2BGAAKMT2AHTR1A | |
| SCHEMBL5399361 | 0.90 | TOP2A (0.41) | TOP2ATOP2BGAAKMT2AHTR1A | |
| SCHEMBL5485333 | 0.87 | TOP2A (0.42) | TOP2ATOP2BGAAKMT2AALDH1A1 | |
| SCHEMBL5440036 | 0.87 | TOP2A (0.41) | TOP2ATOP2BGAAKMT2AHTR1A | |
| SCHEMBL5435055 | 0.81 | TOP2A (0.38) | TOP2ATOP2BGAAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230105-B2 | 9-aminoacridine derivatives and process for the preparation thereof | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2007-06-12 | — | — | US | disclosed |
| US-20050222167-A1 | 9-aminoacridine derivatives and process for the preparation thereof | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222167-A1 | 9-aminoacridine derivatives and process for the preparation thereof | PARP9, CASP9, AMPD2 | TOP2A 131/4885TOP2B 209/4885RBP4 2745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.