CASP9 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1396589	0.59	5/20
SCHEMBL1396473	0.52	5/20
SCHEMBL1396580	0.51	5/20
SCHEMBL950389	0.46	5/20
SCHEMBL952481	0.46	5/20
SCHEMBL1092156	0.67	4/20
SCHEMBL1092160	0.67	4/20
SCHEMBL614741	0.57	4/20
SCHEMBL1396554	0.56	4/20
SCHEMBL1483376	0.55	4/20
SCHEMBL713780	0.52	4/20
SCHEMBL1264575	0.51	4/20
SCHEMBL1396434	0.51	4/20
SCHEMBL811863	0.51	3/20
SCHEMBL1674857	0.50	3/20
Trifluoroacetic Acid (SCHEMBL948554)	0.40	3/20
Trifluoroacetic Acid (SCHEMBL948555)	0.40	3/20
SCHEMBL1217303	0.77	2/20
SCHEMBL1426719	0.56	2/20
SCHEMBL158671	0.56	2/20

Clinical trials — most relevant to CASP9 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer	PHASE4	UNKNOWN
Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?	PHASE4	COMPLETED
Enhancing Effect on Tumour Apoptosis With the Use of Pentoxifylline in Patients With Hodgkin Lymphoma	PHASE4	UNKNOWN
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19	PHASE2	COMPLETED
Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia	PHASE2	COMPLETED
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma	PHASE1	COMPLETED
A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors	PHASE1	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Administration of Autologous CAR-T CD19 Antigen With Inducible Safety Switch in Patients With Relapsed/Refractory ALL	PHASE1	ACTIVE_NOT_RECRUITING
Safety Study of Gene Modified Donor T-Cells in Adults With Advanced Hematologic Malignancies	PHASE1	WITHDRAWN
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Patient-Derived Organoids to Functionally Characterize Chemotherapy Resistance in Breast Cancer	nan	NOT_YET_RECRUITING
EVALUATION OF SALIVARY BİOMARKER LEVELS IN SMOKING AND NON-SMOKER INDIVIDUALS WITH DIFFERENT PERIODONTAL DISEASES	nan	COMPLETED
Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.	nan	UNKNOWN
Potential Role of microRNA 410 and BIRC7 Pathways in Recurrent Spontaneous Miscarriage	nan	COMPLETED
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT	nan	UNKNOWN
Effect of Severe Trauma on PD1 and Its Legend (PD1/L1) on T Lymphocytes and Correlation With Mortality	nan	UNKNOWN
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients	nan	UNKNOWN
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CASP9 binder may also engage these)

Protein	Name	Similarity
Q8C3Q9	—	0.998	Q8C3Q9 →
Q9JHX4	—	0.978	Q9JHX4 →
O89094	—	0.977	O89094 →
CASP14	Caspase-14	0.976	landscape →
Q9TZP5	—	0.976	Q9TZP5 →
Q504J1	—	0.974	Q504J1 →
P55867	—	0.974	P55867 →
Q60629	—	0.973	Q60629 →
Q80UN9	—	0.972	Q80UN9 →
PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0.971	landscape →
Q98943	—	0.971	Q98943 →
Q8VDP3	—	0.971	Q8VDP3 →
ADGRE5	Adhesion G protein-coupled receptor E5	0.971	landscape →
P55865	—	0.971	P55865 →
Q502I6	—	0.971	Q502I6 →
Q3SZ16	—	0.970	Q3SZ16 →
Q5DU56	—	0.970	Q5DU56 →
Q9H3H1	—	0.970	Q9H3H1 →
Q62711	—	0.970	Q62711 →
D3ZBP4	—	0.970	D3ZBP4 →
B3DLB3	—	0.970	B3DLB3 →
A0A0G2K1Q8	—	0.970	A0A0G2K1Q8 →
Q5BJS0	—	0.970	Q5BJS0 →
ENGASE	Cytosolic endo-beta-N-acetylglucosaminidase	0.969	landscape →
P10937	—	0.969	P10937 →
P35283	—	0.969	P35283 →
A0FGR9	—	0.969	A0FGR9 →
Q4R6L3	—	0.969	Q4R6L3 →
Q3TDX8	—	0.969	Q3TDX8 →
CASP2	Caspase-2	0.969	landscape →