Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.40 |
| ▸ | CTSD | P07339 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 7/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5401757 | 0.93 | TOP2A (0.40) | TOP2ATOP2BCTSDKDM1APARP1 | |
| SCHEMBL5398721 | 0.92 | TOP2A (0.47) | TOP2ATOP2BKDM1APARP1KMT2A | |
| SCHEMBL5405656 | 0.91 | PARP1 (0.44) | TOP2ATOP2BKDM1APARP1CYP3A4 | |
| SCHEMBL5401693 | 0.89 | TOP2A (0.43) | TOP2ATOP2BPARP1 | |
| SCHEMBL6159102 | 0.87 | TOP2A (0.46) | TOP2ATOP2BCTSDKDM1APARP1 | |
| SCHEMBL5404233 | 0.86 | TOP2A (0.46) | TOP2ATOP2BPARP1 | |
| SCHEMBL5394368 | 0.85 | TOP2A (0.48) | TOP2ATOP2BKDM1APARP1KMT2A | |
| SCHEMBL5398724 | 0.84 | TOP2A (0.47) | TOP2ATOP2BKDM1AKMT2A | |
| SCHEMBL5405660 | 0.83 | TOP2A (0.41) | TOP2ATOP2BKDM1APARP1 | |
| SCHEMBL5401696 | 0.83 | TOP2A (0.43) | TOP2ATOP2BKDM1APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230105-B2 | 9-aminoacridine derivatives and process for the preparation thereof | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2007-06-12 | — | — | US | disclosed |
| US-20050222167-A1 | 9-aminoacridine derivatives and process for the preparation thereof | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222167-A1 | 9-aminoacridine derivatives and process for the preparation thereof | PARP9, CASP9, AMPD2 | TOP2A 131/4885TOP2B 209/4885CTSD 1587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.